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Jun 10
Why more boys have autism-like symptoms
Behaviours relevant to autism are more frequently observed in boys than in girls, because of naturally occurring sexual difference in characteristic of all children, research has found.

Autism spectrum disorder (ASD) is characterised by social impairments, communication difficulties and restricted, repetitive and stereotyped patterns of behaviour.

"The results imply that there may be an over representation of boys with autism, based on sex differences that affect all children," said principal investigator of the study Daniel Messinger, professor of psychology at University of Miami in the US.

The study followed a large sample of boys and girls at high-risk for the disorder and other children at low risk beginning before 18 months of age.

One in four high-risk boys were identified with the disorder at three years, compared to one in 10 high-risk girls.

The researchers examined how this difference in male-to-female risk of autism spectrum disorder emerged.

They found that boys with ASD had higher levels of a particular autism symptom (stereotyped behaviours) than girls.

The boys with ASD generally had less advanced cognitive and language functioning than the girls.

However, the sex differences in stereotyped behaviours and cognitive functioning were also present in children without ASD.

"We found that girls look a little better than boys in almost every area," Messinger said.

"Children with ASD show typical differences between boys and girls, even though - by virtue of having ASD - they clearly have higher symptoms and cognitive difficulties."

"Our results are important because they show that naturally occurring sex differences characteristic of all children are behind the sex differences we see in autism," he added.

The study was published in the journal Molecular Autism.

Jun 09
Exercise during pregnancy curbs diabetes risk
A little exercise during pregnancy can bring in huge benefits for you and the baby.

Researchers have found that women who engage in moderate physical activity during pregnancy are less likely to have gestational diabetes, and the exercise also helps to reduce maternal weight gain.

"Exercise is not something to be feared during pregnancy - the moderate levels of exercise used in these studies had significantly positive effects on health and were found to be safe for both mother and baby," said lead author of the study Gema Sanabria-Martinez from Virgen de la Luz Hospital in Spain.

Gestational diabetes is one of the most frequent complications of pregnancy. It is associated with an increased risk of serious disorders such as hypertension, preterm birth, and with induced or caesarean birth.

It can have long term effects on the mother including long term impaired glucose tolerance and Type-2 diabetes.

The children of mothers with gestational diabetes are more likely to become overweight or obese and have a higher risk of developing diabetes themselves.

Gaining more weight than is recommended during pregnancy carries similar risks, and these women are also less likely to lose the excess weight after the baby is born.

In this study, analysis of 13 trials, involving more than 2,800 women, found that exercise reduced the risk of gestational diabetes by more than 30 percent - for women who exercised throughout pregnancy this was even greater (36 percent).

This effect was strongest for women who combined toning, strength, flexibility and aerobic exercise.

Exercise was also helpful in reducing excessive weight gain -- those who exercised were on average a kilogram lighter.

This held true for the weight gain even if the exercise programme was started in the second trimester of pregnancy.

The study was published in BJOG: An International Journal of Obstetrics and Gynaecology.

Jun 08
Top salads with eggs to better absorb vegetable nutrition
Adding eggs to a salad with a variety of raw vegetables is an effective method to improve the absorption of carotenoids, which are fat-soluble nutrients that help reduce inflammation, a research has found.

"Eating a salad with a variety of colourful vegetables provides several unique types of carotenoids, including beta-carotene, lutein, zeaxanthin and lycopene," said Wayne Campbell, professor of nutrition science at Purdue University in the US.

"The lipid contained in whole eggs enhances the absorption of all these carotenoids," Campbell said.

Most people do not eat enough vegetables in their diets, and at the same time, people are consuming salad dressings that have less fat or are fat-free," said Jung Eun Kim, postdoctoral researcher in Purdue University.

"Our research findings support that people obtained more of the health-promoting carotenoids from raw vegetables when cooked whole eggs were also consumed," Kim said.

Eggs, a nutrient-rich food containing essential amino acids, unsaturated fatty acids and B vitamins, may be used to increase the nutritive value of vegetables, Kim said.

In the study, 16 participants consumed a raw mixed-vegetable salad with no eggs, a salad with one and a half eggs, and a salad with three eggs at different times.

All salads were served with three grams of canola oil.

The second salad had 75 grams of scrambled whole eggs and the third 150 grams of scrambled whole eggs.

The absorption of carotenoids was 3.8-fold higher when the salad included three eggs compared to no eggs.

The study used scrambled eggs to make sure the participants consumed both the yolk and egg whites.

This research was published online in the American Journal of Clinical Nutrition.

Jun 06
Why soft drinks could make you a couch potato
New York: Diets rich in fructose, carbohydrate derived from fruit and vegetables, may lead to a significant weight gain, physical inactivity and body fat deposition, a new research has found.

Many soft drinks and processed baked goods contain high-fructose corn syrup.

The researchers designed this study based on the intake of fructose by adolescents in the US.

"Our study suggests that such levels of fructose can indeed play a role in weight gain, favour fat deposition, and also contribute to physical inactivity," said Justin Rhodes, professor of psychology at University of Illinois in the US.

"The link between increases in sugar intake, particularly fructose, and the rising obesity epidemic has been debated for many years with no clear conclusions," lead author of the study Catarina Rendeiro from University of Illinois said.

So the researchers studied two groups of mice for two-and-a-half months: one group was fed a diet in which 18 percent of the calories came from fructose, mimicking the intake of adolescents in the United States, and the other was fed 18 percent from glucose.

"The important thing to note is that animals in both experimental groups had the usual intake of calories for a mouse," Rendeiro said.

They were not eating more than they should, and both groups had exactly the same amount of calories deriving from sugar, the only difference was the type of sugar, either fructose or glucose

The results showed that the fructose-fed mice displayed significantly increased body weight, liver mass, and fat mass in comparison to the glucose-fed mice.

Remarkably, the researchers also found that not only were the fructose-fed mice gaining weight, they were also less active.

"We do not know why animals move less when in the fructose diet," said Rhodes.

The study was published in the journal Scientific Reports.

Jun 02
Drinking over 5 cups of espressos dangerous for health
If you are consuming more than five espressos worth of caffeine every day, you are putting you health a risk.

According to the European Food Safety Authority, excess caffeine consumption could cause problems like increased heart rate, higher blood pressure, irregular heartbeat, tremors, nervousness, insomnia and panic attacks, reported the BBC.

As per the report, if healthy adults were 400mg a day, they were still in the safe zone with no health consequences. For pregnant women, the limit is 200mg a day due to the impact on the growing foetus, while in kids 3mg per day for every kilogram the child weighs was been recommended.

The researchers also found that there was no extra risk caused by combining caffeine and alcohol.

Jun 01
Why you should consume 'eggs' with your raw veggies
Next time you visit a salad bar, consider adding cooked eggs to your raw veggies as a new study shows that this combination will increase nutritive value.

Purdue University's Wayne Campbell said that Americans under consume vegetables and here they have a way to increase the nutritive value of veggies while also receiving the nutritional benefits of egg yolks.

The study found that those who ate the highest egg amount with the salad of tomatoes, shredded carrots, baby spinach, romaine lettuce, and Chinese wolfberry increased absorption of carotenoids 3-9 fold.

The carotenoids found in the salad include beta-carotene, alpha-carotene, lycopene, lutein, and zeaxanthin, the latter two being found in egg yolk as well.

Campbell noted that because of this combination, not only are lutein and zeaxanthin available through whole eggs, but now the value of the vegetables is enhanced.

Campbell believes the beneficial effects seen in this college-age population will extend to all populations and ages. His group would like to expand their research to explore the effects on other fat-soluble nutrients including vitamin E and vitamin D. (ANI)

May 30
Impulsive people more prone to 'binge eating'
The more impulsive you get, the chances are the more you will binge eat when you feel low, claims a new study.

According to Kelly Klump, it is human nature to want to turn to something for comfort after experiencing a bad day. But, according to their research, the tendency to act rashly when faced with negative emotions, is a personality trait that could lead to binge eating.

Binge eating refers to the uncontrollable consumption of a large amount of food in a short period of time, and this doesn't just happen because someone's had a rotten day, but is tied to how impulsive you are.

The research determined that people with these eating problems generally have higher levels of negative urgency or a tendency to act impulsively when experiencing negative emotions, than those who do not have pathological eating habits.

Sarah Racine said it is possible that relationships between binge eating and negative urgency reflect impairments in behavioral control over eating when upset.

She added that overeating may instead represent increased sensitivity to rewarding effects of food in the context of negative emotions

Klump believes that if they can treat the underlying tendency to jump to eating when feeling negative emotions like stress then they may be able to help thousands of individuals who suffer from a range of eating disorders.

The study is published in the International Journal of Eating Disorders.

May 29
Major study finds earlier HIV treatment improves health
A major international study sought to settle how soon is best to start HIV treatment - and the advice is don't delay.

People who started anti-AIDS drugs while their immune system was strong were far less likely to develop AIDS or other serious illnesses than if they waited until blood tests showed their immune system was starting to weaken, the U.S. National Institutes of Health announced Wednesday.

The findings are preliminary, but the NIH found them so compelling that it stopped the study a year early, so that all the participants could receive medication as researchers continue to track their health.

How soon should treatment begin?

"The sooner the better," said Dr. Anthony Fauci, director of NIH's National Institute of Allergy and Infectious Diseases, which funded the work.

Current U.S. guidelines already recommend early treatment for HIV, but the findings could alter care recommendations in other countries.

HIV may not trigger symptoms for years, raising the question of how soon after diagnosis patients should begin taking expensive medications that may cause side effects. Previous studies have made clear that early treatment dramatically lowers the chances that someone with HIV spreads the virus to a sexual partner. But there was less evidence that the HIV patient's own health would benefit by starting early.

The START trial - Strategic Timing of AntiRetroviral Treatment - sought proof by randomly assigning still healthy patients either to receive early therapy or to delay therapy until their CD4 cells, a key sign of immune system health, dropped into a worry zone.

While the U.S. guidelines back treatment regardless of patients' CD4 counts, the World Health Organization's guidelines recommend that HIV-infected people begin treatment when their CD4 levels fall below normal, to 500 or below. But that doesn't happen in many poor countries, where often people are sicker before they receive treatment and global funding to expand care is tight.

Even in the U.S., many people don't seek or stick with early care: The Centers for Disease Control and Prevention recently reported that only about 30 percent of Americans with HIV have the virus under control.

The START trial enrolled 4,685 people in 35 countries, all of whom had CD4 counts in the healthy range - above 500 - and had never taken anti-HIV medication. Researchers tracked deaths, the development of AIDS-related illnesses and the development of serious non-AIDS events such as cancer, heart disease and kidney or liver disease.

Over about three years, the risk of serious illness or death was reduced by 53 percent in the early treatment group, NIH said.

The actual numbers of bad outcomes in both groups were very low, given that patients were so healthy when they enrolled in the study: 41 cases in the early-treatment group compared with 86 in the group that delayed treatment until their CD4 count dropped to near 350.

The results, once final, will need careful scrutiny to see if they apply to people with the highest CD4 counts, cautioned Dr. Jay Levy of the University of California, San Francisco, who wasn't involved in the new study.

"I'm still concerned about putting everyone on therapy," Levy said.

But Fauci said the study offers "another reason why we should be more aggressive" in getting people tested and treated. "It tells you that you will benefit from therapy at whatever your CD4 count is," he added.

May 28
Newer contraceptive pills may further raise risk of blood clots
Newer versions of the Pill may raise a woman's risk of dangerous blood clots even more than older versions, a large U.K. study suggests.

Women taking any combined oral contraceptive pills - containing both estrogen and progestin - were three times as likely to develop a blood clot in a deep vein in the leg or pelvis, compared to women not on the Pill. The risk was higher still with all the newer Pill versions except one, researchers found.

"This association is between 1.5 and 1.8 times higher for the newer formulations," said lead author Yana Vinogradova, a research fellow in medical statistics at the University of Nottingham.

The blood clots, known as venous thromboembolisms (VTEs), are common and can be deadly if the clot dislodges and travels to the heart, brain or lungs. They are more common among women taking estrogen medicines, and the risk is even higher if the woman smokes, according to the National Library of Medicine.

But the overall risk of a blood clot for women on any combined oral contraceptives is still relatively low: between six and 14 extra cases per year per 10,000 women taking the drugs, Vinogradova told Reuters Health by email.

Newer combined pills, including the progestins drospirenone, desogestrel, gestodene or cyproterone acetate, have been suspected of carrying an even higher clot risk compared to older versions that include levonorgestrel and norethisterone. But most past studies have been small or flawed by not taking into account certain other risk factors for clots, the study team writes in BMJ.

To assess VTE risk in women on both older and newer-generation pills, the researchers analyzed U.K. general practice databases covering the period between 2001 and 2013. They found 5,062 cases of VTE among women ages 15 to 49, and matched each of these women with up to five women who did not have a blood clot in the same year, but were of similar age and treated at a similar medical practice.

The researchers accounted for smoking, alcohol consumption, race, body mass index and other health problems, and found that women taking any combined oral contraceptive were almost three times as likely to suffer a blood clot as those not taking contraceptive pills.

Women taking older-generation drugs were about 2.5 times as likely to have a blood clot as women not taking any oral contraceptives over the previous year. Those taking newer types of combined pills were about four times as likely to suffer a clot compared to women not taking oral contraceptives.

The exception among the newer formulations was norgestimate, with a risk profile more similar to the older drugs.

The results would translate to a number of "extra" cases of VTE among women taking the combined pills versus women not on the Pill. These numbers were lowest for the older drug levonorgestrel and the newer norgestimate, with an additional six cases per 10,000 women per year, and highest for two newer drugs, desogestrel and cyproterone, with an extra 14 cases each.

"However," Vinogradova noted, "these increased risks of (venous thromboembolism) associated with both the older and the newer pills are lower than those associated with pregnancy," which may increase clot risk tenfold.

The newer pills carry higher clot risk, but were introduced as potentially having new benefits as well, including reduced acne, headache, depression, weight-gain, breast symptoms and breakthrough bleeding, she said.

The association between different oral contraceptives and blood clot risk has been controversial and previous study results have been mixed, but the new findings help to clarify those inconsistencies, Susan Jick, a professor at Boston University School of Public Health wrote in an editorial accompanying the new results.

About nine percent of women worldwide take birth control pills, including 28 percent of women in the U.K., the authors write.

Any women who are concerned should discuss treatment options with their doctor at their next routine appointment, Vinogradova said.

"Some women are at higher risk of (blood clot) because of family history or other medical conditions and doctors will already take account of these factors when advising women regarding their options for contraception," she said.

May 27
Extra 2-minutes walk every hour can add years to your life
A new study has revealed that walking an extra two minutes each hour may offset hazards of sitting too long.

The University Of Utah Health Sciences study suggests that engaging in low intensity activities such as standing may not be enough to offset the health hazards of sitting for long periods of time. On the bright side, adding two minutes of walking each hour to your routine just might do the trick.

Numerous studies have shown that sitting for extended periods of time each day leads to increased risk for early death, as well as heart disease, diabetes and other health conditions. Considering that 80 percent of Americans fall short of completing the recommended amount of exercise, 2.5 hours of moderate activity each week, it seems unrealistic to expect that people will replace sitting with even more exercise.

They found that there is no benefit to decreasing sitting by two minutes each hour, and adding a corresponding two minutes more of low intensity activities. However, a "trade-off" of sitting for light intensity activities for two minutes each hour was associated with a 33 percent lower risk of dying.

Lead author Srinivasan Beddhu said that it was fascinating to see the results because the current national focus is on moderate or vigorous activity. To see that light activity had an association with lower mortality is intriguing.

Beddhu explained that while it's obvious that it takes energy to exercise, strolling and other light activities use energy, too. Even short walks add up to a lot when repeated many times over the course of a week. Assuming 16 awake hours each day, two minutes of strolling each hour expends 400 kcal each week. That number approaches the 600 kcal it takes to accomplish the recommended weekly goal of moderate exercise.

He concluded that based on these results they would recommend adding two minutes of walking each hour in combination with normal activities, which should include 2.5 hours of moderate exercise each week. Moderate exercise strengthens the heart, muscles, and bones and confers health benefits that low and light activities can't.

The study is published in the Clinical Journal of the American Society of Nephrology (CJASN).

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