HowJapanese Encephalitis vaccine effective in India seeing it's regular upsurge ?

Prof.Dr.Dram,profdrram@gmail.com,Gastro Intestinal,Liver Hiv,Hepatitis and sex diseases expert 7838059592,943414355    www.blogspot.com/drnakipuria     www.bhartiyanews24x7.com    www.bhartiyanews24x7.net

JE kills thousand of children in India ,Gorakhpur is always in media for this disease since last 02 decades ,so whether it's vaccination is effective or not is a big questions and all research must be directed to know effectiveness of this vaccination.

  In India, a single subcutaneous dose of SA 14-14-2 JE vaccine offers effectiveness of 72% however, monitoring the efficacy is required post two dose schedule according to a new study.Japanese encephalitis (JE) is an acute central nervous system infection caused by a mosquito-borne flavivirus. Worldwide, almost 68,000 cases are documented every year and predominantly this condition affects children. JE is also quite common in India. While treatment for JE is lacking, availability of the vaccines help in combating the problem.

           In India, mouse brain-derived inactivated JE vaccine was used earlier, but failed to fulfil the national requirement. Following that, another vaccine, the SA 14-14-2 live attenuated JE vaccine has shown a protective effectiveness of 96% after 5 years, but  there has been a lack of enough Indian data to back this claim.

 
              To test efficacy of SA 14-14-2 live attenuated JE vaccine, a community-based 1:4 individually-matched case-control study was conducted among children aged 1–15 years, residents of JE-endemic districts in Uttar Pradesh (UP) and Assam states in India. The study was conducted to assess the efficacy of the live attenuated single dose JE vaccine received by the children in the year 2006 to 2008, during mass vaccination campaigns among children aged 1–15 years. Researchers assessed 149 cases along with matched 596 controls.