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Feb06

URIC ACID (serum)
Elevated in:
Renal failure, gout, excessive cell Iysis (chemotherapeuticagents,radiation therapy, leukemia, Iymphoma, hemolytic anemia), hereditaryenzyme deficiency(hypoxanthine-guanine-phosphoribosyl transferase) acidosis, myeloproliferative disorders, diet high in purines or protein drugs (diuretics, low doses of ASA, ethambutol, nicotinic acid), lead
poisoning, hypothyroidism, Addison's disease, nephrogenic diabetes insipidus, active psoriasis, polycystic kidneys
Decreased in:
Drugs (allopurinol, high doses of ASA, probenecid, warfarin,corticosteroid), deficiency of xanthine oxidase, SIADH, renal tubular deficits (Fanconi's syndrome), alcoholism, liver disease, diet deficient in protein(or)purines,Wilson's isease, hemochromatosis
RHEUMATOID FACTOR
Present in titer >1:20:
Rheumatoid arthritis, SLE, chronic inflammatory processes, old age, infection, liver disease.
LACTATE (blood)
Increased in:
(Without signifigant acidosis): Muscular exercise, hyperbentilation,glucaon, glycogen storage disease, severe anemia, pyruvate infusion,HCO3 infusion, glucose and insulin infusion.(With hypoxia and acidosis): Acute hemorrage, circulatory collapse, cyanotic heart disease, severe acute CHF, acute anoxemia, extracorpeal circulation, epinephrine
(Idiopathic):Milduremia,infections(esp.pyelonephritis), septicemia,cirrhosis, acute pancreatitis (+/-), third trimester of pregnancy,severe vascular disease, leukemia,anemia,chronicalcoholism,subacute bacterial endocarditis, poliomyelitis



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