NEW LATEST ANTI DRUG ADDICTION MEDICINES WITH LESS SIDE EFFECTS

PROF .DRRAM,HIV /AIDS,HEPATITIS ,SEX DISEASES & WEAKNESS expert,New Delhi,India, profdrram@gmail.com,+917838059592,+919832025033,ON WHATSAPP

Drug addiction continues to plague vast numbers of people across the world, destroying and ending lives, while attempts to develop more effective pharmaceutical addiction treatments continue.Here are five of the most commonly prescribed anti-addiction medications, all of which have been proven effective over the years:

Methadone. As a replacement opiate, this drug is one of the most commonly prescribed for those facing an addiction. If you are interested in taking methadone, find a clinic (public or private) that can provide you with the medication, as well as the guidance you require.

Verenicline. If you are addicted to nicotine, this is the type of medication that you want to add to your daily life.

Naltrexone. Do you have an addiction to alcohol? How about opiates? What about both? If you find yourself with this type of addiction, you need to consider the effectiveness of Naltrexone.

Topiramate. While it has been used to treat seizures, it is also effective in terms of dealing with cravings associated with a drug addiction.

Acamprosate. An anti-craving drug, Acamprosate is used to inhibit a neurotransmitter known as gamma-aminobutyric acid.Acamprosate is often associated with diarrhea and headaches. For some, this is a big deal. Others, however, don’t mind a few side effects if it helps them beat their addiction.Before starting on anti-addiction medication, We should consult  with our medical team to discuss the side effects. They can help us weigh the pros and cons, as well as your other treatment options.

       Scientists now report in the Journal of the American Chemical Society the development of a potent new medicine to fight addiction, which might also be an effective treatment for epilepsy and other conditions.Vigabatrin is an anti-epilepsy medication approved by the Food and Drug Administration that has also been shown to be effective against addiction to cocaine, nicotine, methamphetamine, heroin and alcohol in animal models. In humans, vigabatrin eliminates cocaine addiction in 28 percent of patients. It works by blocking an enzyme, ?-aminobutyric acid (GABA) aminotransferase, which breaks down GABA. The result is higher levels of this neurotransmitter in the brain and diminished narcotic-activated release of dopamine. Long-term vigabatrin therapy can have serious side effects however, causing eye damage in up to 40 percent of those treated.

      So, Richard B. Silverman, Stephen L. Dewey and colleagues wanted to develop a more potent inhibitor of GABA aminotransferase with fewer side effects.The researchers designed a compound, CPP-115, that is 186 times more efficient in inactivating GABA aminotransferase than vigabatrin. In this study, they used computational molecular dynamics simulations of CPP-115 in complex with the enzyme to develop a new and improved agent with 10 times greater efficiency. The drug should also be less likely to cause side effects, as it has fewer off-target activities in in vitro tests. In initial rat experiments, the new compound was far better at blocking dopamine release after a cocaine or nicotine stimulus than CPP-115.