Over time, extrinsic and intrinsic factors indiscriminately contribute to aging of the skin. Excess exposure to UV, lifestyle choices such as smoking and alcohol, genetics, concomitant medical conditions, all together influence and aggravate the rate of degradation of skin quality. Age-dependent collagen/elastin break down, loss of hyaluronic acid (HA), epidermal thinning together with a decrease in the amount of water held in the epidermis leads to fine lines, discoloration, dullness, textural changes and wrinkles.

              Conversely, several therapeutic modalities have been developed over time to prevent and reverse the signs of aging primarily in the facial area, but also in the neck, as it has been recognized as an extension of the facial skin that greatly impacts the overall appearance of an individual.From sunscreens to sophisticated energy-based devices such as intense-pulsed-light, fractional lasers, new generation peels, there is a plethora of cosmetic solutions for improving skin quality and reducing wrinkles. Admittedly however, the use of a topical that can have these benefits would be preferred and embraced by patients as the cost-effectiveness compared to other modalities, and ease of use would reign.

                  Over the past decade, topical anti-aging compounds have increased in number, variety, and efficacy in tackling signs of facial and neck aging. Nimni Cream by Hydropeptide is a patented formulation created by Dr. Marcel Nimni for topical application designed to enhance collagen and proteoglycan synthesis comprising in the skin. The product ingredients include many essential amino acids,an antioxidant compound selected from the group consisting of lipoic acid, bioflavonoids, constituents of ginkgo, and isoflavones, soluble in an organic penetrant, and in a quantity sufficient to enhance collagen synthesis in the skin.

                20 patients were randomized in a 3:1 ratio to use either Nimni Cream by Hydropeptide or placebo starting with twice a week application and increasing to daily for 8 weeks. Patient and investigator assessments were conducted on week 4 and 8. At week 8, blinded and treating investigator assessments showed a statistically significant improvement in global aesthetic improvement scale assessments in the active group for the face, but not the neck area. There was also a trend towards improvement in Fitzpatrick Wrinkle Scale scores in the active, but not placebo group, at both time-points, for the face and neck, but the results were not statistically significant.