Thiamine supplementation for patients with septic shock - Welcome To IndiaHeartBeat.Com India's Leading Online Doctor Directory, Live Help

World's first medical networking and resource portal

Community Weblogs

My Blog Browser Bookmark

Jul26

Thiamine supplementation for patients with septic shock

Dr.Dram,profdrram@gmail.com,Hiv,Hepatitis and sex diseases expert +917838059592,+919434143550

Thiamine (vitamin B1) was associated with improved outcomes in patients with septic shock in this retrospective study.Thiamine deficiency is often seen in critically ill patients, and lactic acidosis is a known consequence of deficiency.
Thiamine treatment is safe and inexpensive, and often administered for suspected Wernicke's encephalopathy.A recent pilot study suggested benefit to supplements in patients with septic shock with documented deficiency.
Most patients received 500 mg intravenous thiamine every 8 hours for 72 hours.
With vs without thiamine:Lactate clearance: subdistribution HRs from 1.292 to 1.339, based on 3 competing-risks regression models;28-day mortality: HR, 0.666 (95% CI, 0.490-0.905);For both outcomes, women realized greater benefit than men.
Retrospective matched-cohort study at an academic medical center in Lexington, Kentucky.
From 1049 eligible adults with validated septic shock, researchers compared matched patients who did vs did not receive thiamine within 24 hours of admission (n=123 and 246, respectively).Baseline thiamine levels were not measured.
Nonrandomized study with risk for unmeasured confounders.Thiamine dosing strategies varied.
This patient population had an unusually high rate of cirrhosis.