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Category : All ; Cycle : July 2010
Medical Articles
Jul09
CHRONIC PANCREATITIS: POSTOPERATIVE ANATOMY AND COMPLICATION
Surgical procedures are generally recognized by Pancreatologists as the most effective treatment for chronic pancreatitis in reducing acute exacerbations and chronic symptoms.Surgery performed for chronic pancreatitis can be classified as resection procedures or drainage jejunostomy.Types of pancreatic resection surgery include Whipple and Beger's procedures.Drainage pancreaticojejunostomy procedures include Puestow and Frey's operations.When the pancreatic duct in the body or tail is dilated beyond 6 mm, the puestow procedure is usually most effective.When disease occurs predominantly in the head of the pancreas, Frey's procedure is used.When there is a focal mass in the head without significant duct dilation, the whipple's procedure is most frequently done. Beger's procedure which preserves the duodenum, is also used as an alternative.
Several expected postoperative CT and MRI findings may be confused with disease.Periportal hepatic edema, which usually resolves in 1 month, and pneumobilia which usually persists, are seen universally.The afferent loop of the bowel that drains the pancreatic and biliary ducts may be edematous in the first 3 weeks.This appearance should not be mistaken for bowel ischemia or hemorrhage. The Roux loop may be mistaken for an abscess.In puestow procedure, the Roux loop lies between the stomach and the pancreatic body in the lesser sac and should not be misinterpreted as an internal hernia or pancreatic tumor.Transient fluid collections in the pancreatic and duodenal bed are common in the first month after surgery and do not need to be drained unless clinically indicated. Reactive lymphadenopathy is seen upto 2 months postoperatively.Perivascular cuffing around the celiac, hepatic, and mesentric arteries is seen upto 6 weeks after whipple and Beger's procedures.This finding can be mistaken for tumor recurrence.Mild pancreatic duct dilation is an expected postoperative appearance.After Frey's procedure, a large cavity may be seen in the pancreatic head and may possibly be mistaken for a pseudocyst or cystic neoplasm.Some errors can be avoided if postoperative anatomy is known to the radiologist.


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Jul08
Juvenile Depression
These days we can see the level of competition is too high that it becomes very hard for the children to handle it in the right way. Do not forget their studies and extra curriculum that needs to go the parallel way. Parents too are demanding when it comes to child’s escalated success. We often see parents comparing their children with other’s children, which itself it the root cause of depression. Reality shows, publicity, fame and other kind of competitions coming in our sphere children are soft target for depression. Children don’t play well nor do they get sleep well. They are over loaded with all kind of stuff. The childhood phase in them is been wiped out at a very early stage in life. Unlike adults, children don’t exhibit sadness or express like adults do, so it becomes difficult to recognize whether a child is depressed or not. They hold back their feelings and that in turn leads to stress and depression.


Here are some symptoms that could help you identify juvenile depression.


• Being very irritable or angry or start to respond negatively on anything and everything.
• Becoming unenergetic and not responding to things where it could be fun for them.
• Feeling of not wanted or detected. (This happens usually when compared.)
• Not being able to concentrate and as a result fairing miserably at studies.
• Growth considered improper ie. Gaining and losing weight at a fast pace.
• Obesity in children.
• Crying without reason or anything and everything making them cry.
• Frequent illness.
• Feeling of “I can’t” in life.
• Mood swings. (Suicidal thoughts: take them to a qualified psychotherapist right away)


Tips to overcome juvenile depression.
• Talk to your child and make him/her understand that everyone faces depression.
• Allow the child to express.(If he/she wants to cry; let him/her cry but be with them to support their feelings with encouraging words and action).
• Make the child face the truth. We often try to cover their painful/hurtful feelings. (esp. getting the
child a prize from the shop and gifting when failing to get a prize in the competition).
• Develop confidence of the child in you. This helps them to open-up everything to you.
• Do not over empathize with the child, rather empathize to lead the child back to recovery.
• Make the child understand various other options to excel and be better.
• Schedule time for the child to eat, play and sleep. Do not encourage the child to be obese.
• Develop a hobby of child’s interest.
• Seek opinions from them for decisions at home. This is helpful in implanting a feeling of being
wanted and/or getting them mature to situations.
In spite of trying out all these if the child do not respond take him/her to a qualified psychotherapist who could assist your effort in leading the child out of situational depression.
Every child is unique and let him/her be what he/she is and excel in their field of interest. Bring the smile back on the child’s face.


Dr. Kurien S. Thomas
Executive Director
Effective Living Inc


Dr.Kurien S. Thomas is a writer, columnist, corporate trainer, psychotherapist, yoga therapist & counsellor; Founder & Executive Director of Effective Living Inc., a global counselling, k yoga & stress management clinic, which has a unique approach to psychotherapy, counselling, yoga therapy & wellness therapy. He also conducts seminars and workshops for corporate, schools, colleges and various organisations.


His personal / online counselling on family issues, teenagers, parenting, health issues, obesity, slimming, alcoholism and other issues has been a boon to many with 100 % confidentiality assured.


For more details and appointments write to him here or call at: +91-0-9969105310 or +91-0-9987223811. Website: www.effectivelivingonline.com


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Jul07
Lobar Pneumonia treated successfully with Homoeopathy
Patients Initial: A S
Age: 02 months
Sex: Male
Date of Case taking: 5th Oct’08
Treating Physician: Dr. Nilesh J Shah M D (Hom) Bhakti Homoeopathy Dispensary, Pune – 37.
Probable Clinical Diagnosis: Lobar Pneumonia clinically diagnosed with High grade fever, cough, Chest auscultation findings of coarse crepitation in right mid zone.
O D P: Patients mother called up at 6:00 p.m. saying that doctor Abdullah is admitted for past four days and his fever is not coming down yet. Further mother said that he is very restless for past four days is continuously crying and is not pacified by any thing or in any way. He has not slept for past four days nor any one of us have slept. Please doctor if you can come and see him in the hospital.
This is all what the mother had narrated and I assured her that I will come after my clinic hours. I had repertorised before going to the hospital and had taken the medicine.
On approaching hospital I saw that the child was sedated as he was restless, and he had fever.
Presently on visiting he c’s /o
Location Sensation Modality Concomitant
Lung, Right side Pneumonia Crying continously not knowing for what nil
Not relieved by any act
Past history: Recurrent history of cold coryza since birth

References:
Repertory: Synthesis
Complete
Materia Medica: Clarke’s Dictionary
Close coming remedies:
1. Cina
2. Ars A
Final Prescription: Chamomilla

Potency: Cham 200 single dose on 5th Oct’08
S L 4 pills TDS
Patient was having good susceptibility and the disease was of Acute nature.
Remedy Repetition: Single dose was prescribed
Follow up next day
Follow up Analysis
6th Oct’08 Mother called at 8:00 a.m. saying doctor thank you very much we all could sleep yesterday. That is all what was required. She said that there was no fever since night and had peaceful sleep. And asked what next to do, we kept him on SL
7th Oct’08 She again called and said doctor since yesterday he is passing green stools, I asked her whether he was at ease or not, she said he is at ease and again I advised her to continue with SL pills
8th Oct’08 Patients grand mother came to my clinic and said that in hospital

Learning from the experience of this case
1. Acute cases also need to be worked with prime importance paid to the altered state of Mind.
2. Do not get baffled when particulars are not found in Materia Medica
4. Homoeopathy works FASTEST confirming Aphorism 1 & 2.


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Jul07
Post Operative Acute Epididymo orchitis cure with Homoeopathy
A Case: by
Dr. Nilesh Jitendra Shah
Bhakti Homoeopathy Dispensary, Pune – 37.
Mobile: +91 98223 93060

CASE OF CALC CARB IN ACUTE EPIDIDYMI-ORCHITIS {A Post-Op Complication After Trans-Urethral Resection Of Prostate.}

Patients Initial: S M P Age: 58 years Sex: Male
Date of Case taking: 10th Nov’08
Treating Physician: Dr. Nilesh J Shah M D (Hom)
Probable Clinical Diagnosis: Acute Epididymo-orchitis following T U R P done one & half month back (25/09/08) Clinically diagnosed with swelling redness pain etc and Routine Urine report showing abundant Pus cells within ten days of T U R P
O D P: Patient said that he was admitted for the same (Acute Epididymo-orchitis) again and was given allopathic mode of treatment and was advised by his Surgeon to take Homoeopathic medicine as he did not have relief either in pain, nor in his urine c/o, i.e. pain while urination and also Urine routine report always showed abundant Pus cells.
Patient when came on 10th Nov 08 narrated the above history and said that it all has taken very long as he is in Govt. service & about to retire, he is more worried that all the leave that he has to take now is L W P (Leave without pay) and the Surgeon has again asked him to get admitted after getting fresh Urine Culture and Sensitive report so that they can start him on fresh course of Antibiotics. He is worried and says “itna paisa kaha se lane ka” and said “ab aap hi dekho kya karma chahiye”. He was so curious about his c/o that this time he got his Urine routine report and Culture and Sensitive report done at two different place of same Urine sample as he was doubtful about the reporting that he had got earlier.

Presently on visiting he c /o
Location: Scrotum, right side
Sensation: Pain throbbing, sore
Modality: worse from Touch, Rubbing,
better byRest, Lying still

Final Prescription: CALC CARB

Potency: Calc Carb 200 single dose on 10 / 11 / 08
S L 4 pills TDS
Patient was having good susceptibility and the disease was of Acute nature.
Remedy Repetition: Single dose was prescribed
Follow up after Two days
Follow up Analysis
12 / 11 / 08
Pain less by 50 %
Anxiety while talking relieved
Did not utter about his leave
Infact asked to give him Medical certificate so that he can join his job
Confirmed doubtfulness by getting fresh Urine routine report done at three different places
Seeing the curiosity to join his job and on noticing the above fact CALC CARB 1m single dose was prescribed followed by SL
Urine report was shown on 13/11/08 Pus cells 25 – 30 / hpf which earlier was abundant
17/011/08 C / o >>> was kept on SL
22/11/08 C / o >> Patient said “tichki marlya sarkhe wat te”
Had got his Urine report done at one place only which showed Pus cells 15 – 16 / hpf
So was still kept on SL
Learning from the experience of this case
Homoeopathy works FASTEST


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Jul06
BATTLE
Many clinical research groups have studied the possibility that cancer therapy can be selected on the basis of specific mutations suspected of driving cancer growth, but the new initiative, called BATTLE (Biomarker-integrated Approaches of Targeted Therapy for Lung cancer Elimination), is testing the hypothesis with a high degree of rigor. In BATTLE, molecular features of the tumor entirely drive the treatment selection.The basis is to stop looking at drugs and start looking at the individual tumors.The traditional way has been a retrospective analysis of tissue samples to stratify response rates by tumor characteristics.The new way is to base therapy on the tissue characteristic of the biopsy taken at diagnosis.It is a very important study which shows that it is possible to collect tissue and evaluate it for biomarkers in a time frame, that is acceptable for directing therapy.


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Jul05
Homeopathy n' Steroids...
DO HOMEOPATHIC DRUGS CONTAIN STEROIDS ?

The answer is a definite '‘NO'’.
When appropriate Homeopathic medicines act fast & help acute conditions, people often ask or feel that the physicians are using steroids in the garb of Homoeopathy for quick results.
First of all, can steroid cure all the conditions? No, it will give only a palliative relief for the time being. Also, if you take steroids for a long time, it would induce puffiness of face ‘moon face’, excessive body hair, osteoporosis, weight increase etc. You can’t find in a single patient using Homeopathic drugs any of the above symptoms of steroid drugs. We don’t use any steroidal drugs since it is against the law of Homeopathy. i.e. steroid suppresses the immune mechanism where as Homeopathy stimulates the immune mechanism for expelling the disease.
The commonly performed test to find out steroids is the "Colorimetric Method test" which gives a false positive result for any reducing sugar & aldehyde. As you know, most homoeopaths use lactose as a base for holding the pills, containing the homeopathic remedy, together in the powders. The pills themselves are made of cane sugar, a reducing sugar. Moreover, almost all Homeopathic remedies have alcohol as a diluting agent. One can see how Homeopathic remedies, either as pills, powders or in alcohol, are likely to give a false positive test for steroids if this method is used. The best test to find out if the medicine contains steroids is the "Liberman Buchard" test, Thin Layer Chromatography Method & a UV Absorption Method. This method helps in differentiating & finding out if the substance indeed contains steroids.
Thus it is clear that before accepting a claim that the tested medicine does contain a steroid, one must find out what testing procedures were used to eliminate the possibility of a misleading result. Unsubstantiated allegations against any doctor or system of medicine are most unfair and damaging to his professional integrity and indeed to the profession.
Homeopathic medicines are completely safe and non-addictive. They can be used without any anxiety by anyone, including small babies, children, pregnant women, breast-feeding mothers, the elderly, and the chronically ill.


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Jul05
Synergy - A common platform to learn n' share Homeopathy
Dear Homoeopaths…
Hello…
Before a decade, we all were pass out students of Homoeopathy… We wanted 2 practice homoeopathy but we were not sure which way should we start our practice ‘cause learning homoeopathy in a college classroom n’ practicing it in our own clinic is all together a diff game. But fortunately we came across some of d homoeopaths who selflessly guided us, allowed us to sit with them in their OPD n’ spared their precious time for sharing their knowledge as well as experience even on Saturday-Sundays… We all r grateful 2 all d teachers who helped us n’ many other homoeopaths during our ‘pa pa pagli time’ in homoeopathy… Just 2 keep d tradition on, we all have decided to serve d homoeopathic fraternity in a little way we can… n’ as a first step of it, we’ve planned 2 share our knowledge n’ experience to a group of 10-15 homoeopaths who r committed n’ dedicated 2 Homoeopathy n’ wants 2 build their carrier in Homoeopathic field.
This will be a group of 10-15 homoeopaths meeting twice a month (Sunday morning), covering theoretical aspects of homoeopathy as well as case discussion of video cases.

Fees: Free of charge
Time: 1st n’ 3rd Sunday of every month
Venue: ‘Homeo Care’, UGF-14, Goyal Plaza, Opp. Reliance Jewels, Judges Bunglow Road, Vastrapur, Ahmedabad-380015.
Phone: 079 66053536

To enroll urself, pls send Ur application with Ur resume.

As d seats r very limited, pls confirm ur seat asap if u’r sincerely interested…

For any information ‘bout d same,

Contact:
Dr. Dhiren Kubavat (09825744457)


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Jul02
LAPAROSCOPIC NISSEN FUNDOPLICATION
Gastro Esophageal Reflux Disease (GERD ) is a very common digestive disorder. Medical therapy , involving acid suppression and promotility agents are very effective for a majority of these patients but a small number of these patients do not get complete relief. Laparoscopic fundoplication is a procedure performed for patients with symptomatic GERD refractory to medical management and that which is associated with hiatal hernia .The problem lies at the junction of the esophagus and stomach where a muscular valve should prevent acid from backing upwards. If this sphincter mechanism fails, acid is free to reflux up into the food pipe and cause damage. The surgery basically augments this sphincter by wrapping a portion of the stomach known as the fundus around the lower esophageal sphincter.Before the laparoscopic approach was developed, this surgery required a large incision and the hospital stay was long. Laparoscopic fundoplication is a safe procedure, and provides less post operative morbidity in experienced hands.The fundus of the stomach which is on the left of the esophagus is wrapped around the back of the esophagus until it is once again in front of this structure.The portion of the fundus that is now on the right side of the esophagus is sutured to the portion on the left side to keep the wrap in place.The fundoplication resembles a buttoned shirt collar. The collar is the fundus wrap, and the neck represents the esophagus imbricated into the wrap.This has the effect of creating a one way valve in the esophagus to allow food to pass into the stomach, and prevent reflux of gastric acid.


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Jul01
INTRACTABLE CANCER PAIN :EFFECTIVE INTERVENTIONAL PAIN MANAGEMENT : DR. NEERAJ JAIN, M.D., FIPP (USA) 9810033800 (M)
Dr. Neeraj Jain. M.D.
Senior Consultant Interventional Pain Specialist.
Spine & Pain Clinic, Pitampura, New Delhi-110088.
Head, Department of Pain Medicine, Sri Balaji Action Medical Institute, Delhi.
Incharge Pain Clinic, Rajiv Gandhi Cancer Institute & Research Centre, New Delhi.
9810033800(M),

Pain is a major symptom of cancer and occurs at all stages of the disease. In addition, pain is usually a hallmark of progression or metastatic spread, and 65 to 85 percent of people with cancer have pain when they develop advanced disease. In 10 to 20 percent of cancer cases, pain is difficult to treat, frustrating, and poorly controlled. Currently, opioid pharmacotherapy is the principal weapon in the fight against cancer pain; but when less invasive treatments are unsuccessful, invasive interventions should be added to optimize pain relief. Interventional pain procedures target neural and non-neural pain generators and neural blockade techniques provide excellent pain relief for neuropathic, sympathetic, nociceptive somatic, or visceral pain. Neural blockade techniques are broadly categorized into non-neurolytic and neurolytic blocks.



Non-Neurolytic Blocks
Local anesthetic and corticosteriod blocks are used to treat a variety of pain syndromes. They can also predict how a patient will respond to neurolytic blocks. A good response to non-neurolytic interventions usually means the patient will benefit from neurolytic procedures as well. Fluoroscopic guidance improves the accuracy of these blocks and minimizes complications. Somatic, sympathetic, and neuropathic pain respond to local anesthetic injections or the continuous administration of anesthetic drugs through a catheter. Intercostal nerve blocks or interpleural analgesia are indicated in post-thoracotomy chest wall pain/intercostal neuralgia, and radiculopathy requires selective nerve root blocks or transforaminal epidural injections when non-invasive treatments fail. Sympathetic blocks and other regional anesthetic techniques are employed in sympathetically maintained pain states, ischemic pain, postherpetic neuralgia, and radiation plexopathy

Neurolytic Blocks
Alcohol and phenol are the preferred agents for neurolytic procedures because they cause axonal degeneration within minutes and effectively interrupt the central transmission of pain impulses. Chemical neurolysis can result in immediate and total pain relief in selected patients with localized or regional pain. Opioid requirements decrease sharply, and patients on high doses of opioids will require careful tapering to avoid respiratory
depression. Other indications for neurolysis are costopleural syndrome and sympathetically maintained pain in Pancoast’s syndrome. Unfortunately, potentially unacceptable side effects limit the utility of neurolytic blocks; but neurolytic blocks are still preferred over standard opioid analgesia to control intractable abdominal, pelvic, and perineal pain. The following four criteria must be met before a nerve block is considered appropriate: --Limited lifespan of three to six months --A favorable risk to benefit ratio (i.e., the block will not impair bladder or bowel function or cause limb paralysis) -- A poor response to primary antitumor treatment, which has not been able to reduce the tumor burden -- A good analgesic response and acceptable side effects with prognostic blocks.
Advantages: The neurolytic blocks have the following advantages in home care by relatives of patients particularly in rural area of India: 1). Neurolytic blocks provide longer duration of pain relief. 2).Drugs and inexpensive equipment required are readily available.Elaborate equipment is not mandatory. 3). Long-term indoor ward treatment is avoided, repeated visits to the urban pain center are not required. 4). Patient can remain at home pain free even in rural areas where medical help is scarce.

Table 1. AUTONOMIC NERVE BLOCKS
Neurolytic Block Site/Condition Treated
Stellate ganglion Head Neck or arm pain
Gasserian ganglion Trigeminal neuralgia and facial pain
Interpleural (thoracic sympathetic chain) Upper—head, arms
Middle—thorax, heart, lung
Lower— abdominal organs, uterus, bladder
Celiac plexus (splanchnic nerves) Pancreatitis, Hepatobiliary Cancer pain, visceral/GIT cancer pain upto trans. Colon.
Lumbar sympathetic Lower limb pain, retroperitoneal pain
Hypogastric plexus Pelvic, Perineal, urogenital pain
Sacrococcygeal ganglion (impar, Walther) Rectal, uretheral, perineal, vaginal pain

Neurolytic Celiac Plexus Blocks (NCPB) And Splanchnic Nerve Blocks (SNB) are routinely performed (and are preferred over standard analgesic therapies) for patients with intractable pain from pancreatic and upper gastrointestinal cancer. NCPBs provide immediate and substantial pain relief in 70 to 90 percent of cases, improve the patient’s quality of life, and significantly reduce opioid intake. The procedure can be repeated in three to six months if the effect of the initial block wears off. NCPBs are performed percutaneously or intraoperatively. Under radiologic guidance, 50 to 100 percent alcohol is instilled anterior to the aorta at the level of the L1 vertebral body. Injection site pain, diarrhea, and temporary hypotension are transient adverse effects. A low complication rate is observed, since the risk of the neurolytic agent spreading to the somatic nerves supplying the lower limbs, bladder, and bowel is minimal
Superior Hypogastric Plexus Blocks (SHPB) are indicated for unrelenting pain from cancer of the pelvic viscera. This plexus lies in front of the L5 and S1 vertebrae in the prevertebral space. A spinal needle is placed percutaneously in this space from the back under radiologic guidance. Excellent analgesia is reported by 70 percent of patients after a SHPB. Reductions in pain scores and opioid consumption are reported to be significant, even in patients with advanced disease. No major complications have been reported following SHPBs, although a potential risk exists for the spread of neurolytic agents to the nerve fibers controlling micturition, bowel motility, and sexual function. The SHPB block can be repeated if pain recurs. Patients who fail two consecutive attempts are candidates for intraspinal opioid analgesia.

Ganglion Impar Neurolytic Blocks relieve perineal pain from cancer of the cervix, endometrium, bladder, and rectum. The ganglion is a single, midline structure ventral to the sacrococcygeal junction and can be accessed by a midline trans-sacral approach.
Painful input from somatic and visceral structures can produce sympathetically maintained pain (SMP) that may be visceral or neuropathic in nature. Sympathetic Ganglion Neurolysis relieves SMP and improves blood flow and is used to treat pain from radiation plexopathy, phantom pain, herpes zoster, vascular insufficiency secondary to malignancy, and complex regional pain syndromes (reflex sympathetic dystrophy and causalgia), with little risk of motor or sensory loss or deafferentation pain.
The trigeminal nerve receives sensory input from the skin of the face, anterior two-thirds of the tongue, and oronasal mucosa. Anesthetic Blockade Or Chemical Rhizolysis of the trigeminal ganglion or its individual branches is indicated in orofacial malignancies with intractable head and face pain.

Neurolytic Spinal Blockade can produce profound segmental analgesia. Nociceptive input is interrupted by selectively destroying the dorsal roots and rootlets between the spinal cord and the dorsal root ganglia. The procedure is reserved for terminally ill patients with cancer who have a short life expectancy and unilateral somatic pain localized to a few adjacent dermatomes, ideally in the trunk and distant from sphincter or limb innervation. Combined with a unilateral cordotomy, subarachnoid phenol blocks effectively control pain in costopleural syndrome, which is caused by invasion of the pleural cavity and thoracic wall. Adverse effects include PDPH, meningitis (rarely), persistent numbness and paresthesia, loss of motor function due to the unintended neurolysis of ventral rootlets, and sphincter and limb weakness.

Trans-sphenoid Pituitary Neuroablation: Chemical Hypophysectomy
Very useful simple intervention with 70-80% success rate in diffuse cancers of advanced stage with multiple bony & spinal metastasis especially hormone dependent cancers not responding to all other measures.
3) Intraspinal Opioid Therapy
continued administration of opioids intrathecally or epidurally with or without dilute concentration of local anesthetic& adjuvant drugs is an important option for patients with thoracic, abdominal or pelvic cancer pain that is refractory to conventional pharmacologic management. Advantages include profound analgesia, often at a much lower opioid dose without the motor, sensory, or sympathetic block. However combinations of low-dose opioids given epidurally with a local anesthetic act synergistically to produce effective analgesia while decreasing the side effects. Administration can be carried out using a variety of drug-delivery systems ranging from a temporary percutaneous epidural catheter to a totally implanted system. The effectiveness of preimplantation procedure and reversibility of effect makes this an attractive treatment option.



Conclusion
The management of patients with cancer pain can be a challenging task, even for physicians trained in cancer pain management Effectively relieving pain in cancer patients requires a range of treatment alternatives, including neural blockade when the patient’s pain no longer responds to opioid analgesia. The type of neural block selected is determined by the location and mechanism of the pain, the physical status of the patient, the extent of tumor spread, and the technical skill and experience of the person performing the intervention. Non-neurolytic blocks can provide safe and effective analgesia for the less serious conditions indicated above. Neurolytic blocks, with their potential for complications, are reserved for select patients who are unresponsive to standard analgesic pharmacotherapy and/or are at a more advanced stage of disease. However, few would question that aggressive intervention is often appropriate. Neurolytic nerve blocks offer an excellent option for the physician in the fight to control cancer pain. Such blocks can be easily utilized to help provide cancer pain relief in most of patients at the utmost needed times.


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Jul01
OZONE DISCECTOMY (OZONUCLEOLYSIS) FOR DISC PROLAPSE ( CERVICAL & LUMBAR): DR. NEERAJ JAIN M.D., FIPP (USA) 9810033800 (M),
DR. NEERAJ JAIN M.D., FIPP (USA)
SENIOR CONSULTANT INTERVENTIONAL PAIN SPECIALIST
SPINE & PAIN CLINIC, RU23 PITAMPURA, NEW DELHI. &
SRI BALAJI ACTION MEDICAL INSTITUTE
(M)09810033800

Ozone Discectomy is the injection of Ozone inside the intervertebral disc in trouble. This is done as an outpatient under local anaesthesia with strict real time radiological control, which ensures the proper placement of Ozone in the center of the disc making it shrink.
LOW BACK PAIN, SCIATICA & PIVD:
Among working age people, as many as 20 percent experience back symptoms at least
every year. spinal diseases are the most common cause of disability in persons under the age of 45. Spine care results in expenditures two to three time greater than cardiac services for many health plans. While there is no specific data related to India, spine surgeons estimate that roughly 5% of the general population is affected by serious disc problems.

Some of the main causes of back pain include facet arthropathy, sciatica, muscle strain, sacroilitis, bulging or herniated discs and degenerative disc disease. Prolapsed intervertebral discs (PIVD) are the most common cause of low back pain associated with a defined structural Abnormality.

Patients who are not helped by weeks of conservative therapy are often referred for
surgery on the premise that further non-operative care is unlikely to help. Ideally, a patient with low back pain that has persisted beyond a four-week period should be referred to a multidisciplinary pain centre.

Different Non Surgical Interventions Employed Successfully:
. Epidural Steroid Inj.
. Epidurogram & Epidurolysis.
. Nerve root sleeve/ transforaminal Inj.
. Intra-discal steroid inj.
. Nucleoplasty- Laser, Thermal & Mechanical
. Ozone Discolysis

Conventional treatment methods for back pain comprise lamminectomy/ discectomy microsurgery, endoscopic disectomy and percutaneous arthoscopic disectomy, among others. These are invasive methods and their goal is to remove or contain the protruding disc. However, these methods have occasionally demonstrated a discrete incidence of failure and/or recurrence. Outcome studies of lumber disc surgeries documents, a success rate between 49% to 95% and re-operation after lumber disc surgeries ranging from 4% to 15%, have been noted. "In case of surgery, the chance of recurrence of pain is nearly 15 per cent as against less than three percent in Ozone treatment.
Reasons for the failures of conventional surgeries are:
1. Dural fibrosis
2. Arachnoidal adhesions
3. Muscels and fascial fibrosis
4. Mechanical instability resulting from the partial removal of boney & ligamentous structures required for surgical exposure & decompression
5. Presence of Neuropathy.
6. Multifactorial etiologies of back & leg pain , some left unaddressed surgically.
THE NEED FOR NEOTECHNOLOGY:
. The various treatment options has confused clinicians and investigators due to high failure rate and complications associated with different kinds of surgeries and interventions. There has been surge of interest in search of safer alternative method of decompressing the nerve roots maintaining the structural stability.
. Another safe least invasive alternative therapy that has been receiving exposure in Europe is the use of medical Ozone (02/03 mixture) in the treatment of PIVD. Epidural steroid injection, transforaminal epidural decompressions has a high success rate (up to 85%), but chances of recurrences are there specially if these interventions are done at later stage. Chemonucleolysis using chymopapain has also high success rate (80%) with low recurrences but not popular owing to the chances of anaphylaxis following intradiscal chymopapain injection. Injection of Ozone for discogenic radiculopathy (low back pain with radiation to legs) has developed as revolutionary alternative to chemonucleolysis and disc surgery .

THE OZONE REVOLUTION IN DISC DISEASES:
Muto suggested intradiscal injection of Ozone for disc hernia in 1998 under CT guidance. Leonardi popularized fluoroscopy guided Ozone injection into the intervertebral disc. After that successful outcome has been reported from various European centers. It is very important to note from those reports that complications are remarkably few. Not a serious single life threatening complication was found even after 120,000 cases of Ozone nucleolysis, which stresses the safety of these procedures.

The most critical portion of performing any of the minimally invasive procedures is accurate and safe positioning of the needle (or terminal device) in the centre of the disc space. The risk in ozonucleolysis is particularly minimised, with the use of a very thin 22/25-gauge needle. It may take anywhere from 5 to 30 minutes to position a needle in the centre of the disc space under radiological guidance. Once the needle is safely placed in position, ozonucleolysis is completed in only another 2 to 3 minutes.

HOW DOES OZONE WORK ?
There are four main biochemical actions on the intervertebral disc and its surrounding tissues. The various proposed mechanisms of action are:


. BY “MUMMIFICATION” OF THE DISC.
. Intra/intermolecular Bonds and collapse of the threedimensional Structure of the disc.
The plausible mechanism of action is the direct effect of the ozone on the Herniation. It is well established that the nucleus pulposus (the actual part of the disc that herniates through annulus) is 70-90% water contained within the domain of proteoglycans. The water binding capacity of the proteoglycan molecule is partially a property of its size and physical shape, but the main force that holds water to the molecule stems from the ionic, carboxyl (COOH) and sulphate (SO4) radicals of the glycosaminoglycan chains. The ozone can have a direct effect on these carboxyl and sulphate groups, breaking down some of these glycosaminoglycan chains which make up the proteoglycans. The destruction of these cross-linked structures reduces their ability to hold water therefore diminishing the size of the herniation by dehydration of the fibrillary matrix of the nucleus pulposus, revealing collagen fibers and signs of regression (vacuole formation and fragmentation)- a sort of disk “mummification.”

. BY INHIBITING INFLAMMATORY NOCICEPTORS.
. Synthesis of Prostaglandines & Secretion of Proteinases
. Liberation of Bradykinines and Pain Inducing Products
. Several studies suggest disc inflammation as a mechanism of sciatica due to disc herniation. Ozone has been shown to have an effect on the inflammatory cascade by inhibiting synthesis of proinflammatory prostaglandins or release of bradykinin or release of algogenic compounds; increased release of antagonists or soluble receptors able to neutralize proinflammatory cytokines like interleukin (IL)-1, IL-2, IL-8, IL-12, IL-15, interferon, and tumor necrosis factor. Therefore, by reducing the inflammatory components there is a corresponding reduction in pain.

. BY STIMULATING FIBROBLASTS & IMMUNOSUPPRESSOR CYTOKINES
. Local production of Antioxidant Enzymes
. Release of immunosuppressor cytokines like transforming growth factor, and IL-10
. Another action which may prove to be one of the most important is the stimulation of
fibroblastic activity by ozone. Fibroblasts initiate the repair process by stimulating the
deposition of collagen. Although yet to be validated, this mode of action could
explain the resolution of PIVD on CT scans and the small percentage of patients who
have relapses after the completion of treatment plan.
. “Ozone may have a reflex therapy effect called ‘chemical acupuncture’, breaking the chain of chronic pain stimulating anti-nociceptor analgesic mechanism. As pain is multi-factorial, ozone may also have a multi-factorial pharmacological effect alleviating disc compression by shrinkage of the herniated disc.”

. BY IMPROVING MICROCIRCULATION & OXYGENATION.
. The direct effect is the oxygen directly diffusing into the area.
. The indirect action is the Ozone causing an increase in 2,3-DPG (diphosphoglycerate) which has a direct effect in the release of O2 from hemoglobin.. The end result is an increase in the amount of oxygen and a reduction in anoxia.
. Disk shrinkage may also help to reduce venous stasis caused by disk compression of vessels, thereby improving local microcirculation and increasing the supply of oxygen.
This effect has a positive effect on pain as the nerve roots are sensitive to hypoxia.

RESULTS & SAFETY:
In a multi-centre, retrospective 3 year follow-up study of lumber disc herniation treated with European Neurosurgical Institute protocol of ozone therapy in 917 patients showed 78.9% good & excellent results with only one case of disc infection which healed with antibiotic.
In fact, over 120,000 patients have been treated successfully worldwide using injection of medical ozone with a success rate of 80-90% and with a near nil rate of procedure-related complications. “The procedure is a safe and effective alternative to open surgical procedure. Patients get the advantage of going home after a short recovery on the same day. They generally go to work within a week and are spared prolonged absence from work and disability,” The treatment relieves pain substantially and, after two sittings, people "can go back to work under medical guidance".

COMPARISON: SPINAL SURGERY OZONE DISCOLYSIS
1 .More Hospital One day/Day Care.
2 Complications of prolonged surgery& anaesthesia GA is not required
3 “failed back surgery syndrome” No “failed back
surgery syndrome”
4 HighCost Total cost is 1/5th to 1/10th
5 Failure rate 10-51% Comparable 10-21%
6 Safety profile comparatively not so high. Very
high safety prorofile
7 Repeat surgeries are more complicated. May be safely repeated many times
8 Cervical PIVD poses a surgical challenge Ideal procedure in cervical PIVD
9 Highly invasive very demanding surgery Least invasive much easier procedure
10 High postoperative morbidity
Negligible morbidity
11 In-patient major surgery Mostly OPD procedure


CONCLUSION:
Ozone Discectomy a revolutionary least invasive safe & effective alternative to spine surgery is the treatment of choice for prolapsed disc (PIVD) done under local anaesthesia in a day care setting. This procedure is ideally suited for cervical & lumbar disc herniation with radiculopathy. Total cost of the procedure is much less than that of surgical discectomy. All these facts have made this procedure very popular at European countries. It is also gaining popularity in our country due to high success rate, less invasiveness, fewer chances of recurrences, remarkably fewer side effects meaning high safety profile, short hospital stay, no post operative discomfort or morbidity and low cost.

DR. NEERAJ JAIN
09810033800


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