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Category : All ; Cycle : July 2010
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Jul01
PAIN MANAGEMENT : NEW SUPER-SPECIALTY::- DR.NEERAJ JAIN M.D., FIPP (USA) 9810033800 (M)
PAIN MANAGEMENT :
NEW SUPERSPECIALITY::- DR.NEERAJ JAIN M.D.
9810033800 (M)

“It is easier to find a man who will volunteer to die, than to find those who are willing to endure pain with patience” Julius Caesar

Remember:-“No one dies of pain but many die in pain and many more live with pain” “Freedom from pain is human right”

Pain is 5th vital sign as per W.H.O. Pain is now understood as primary medical condition. “The neurosignature of pain experience is determined by the synaptic architecture of the neuromatrix”

Pain Medicine, a super-specialty, deals with the management of these difficult chronic painful disease states including treatment of cancer pain. A majority of complex chronic painful states, unresponsive to conventional treatment are being successfully treated at Pain Clinics. The very concept of a Pain Clinic is based on the conviction that the effective management of difficult pain conditions is possible only through well-coordinated efforts of a specialist possessing knowledge and skills to diagnose and treat pain.

A Pain Clinic uses services of specialties such as neurology, psychology, physical therapy, orthopedics, anaesthesiology and neurosurgery. “Comprehensive multidisciplinary pain management centre” is the highest pain management facility/ centre of excellence, which is equivalent to super specialty cardiac / neuro / nephrology centre.

Thus, Pain Clinics are specialized areas that are now assuming the role of an essential service as they meet a need unmet by any previously existing medical facility. They help by simultaneously treating the physical, emotional, cognitive, behavioral, vocational and social aspects of chronic pain cost-effectively.

Chronic pain is a disease, a syndrome not just a symptom.
Chronic pain can lead to depression, anxiety, marital & interpersonal problems, decreased productivity, unemployment, compromised social roles, isolation, financial burden, dependence, prolonged analgesics usage, decreased self esteem with behavioral changes adversely affecting quality of life (QOL) & activities of daily living (ADL).
“The pain of mind is worse than the pain of body”
“Chronic pain is something you wear on inside, not on the outside”
“Not tonight, dear. I have a backache.” Backache is second only to headaches as the most common location of pain.
Pain is one of the most common reasons for patients to seek medical attention and one of the most prevalent medical complaints in today’s world.
Some 75 million Americans experience persistent pain and at least nine per cent of the USA adult population is estimated to suffer from moderate to severe non-malignant pain. Patients with chronic (or “persistent”) pain can be especially difficult to treat. In one survey conducted for the American pain society, 47 per cent of those with moderate, severe or very severe pain had challenged physicians at least once since their initial visit for pain relief. When asked why, they cited continued suffering (42 per cent), the physician’s lack of knowledge (31 per cent), not taking the pain seriously enough (29 per cent), and unwillingness to treat it aggressively (27 per cent) as reasons for the change. Situation in India is not very different from this one.
Despite these startling statistics pain still remains inappropriate & inadequately treated. Although tremendous scientific & technological advances have been made, the knowledge & techniques are highly underutilized. This is due to lack of dissemination of information to clinicians. “It’s easy to be paranoid when you hurt like hell and you are on the mercy of healthcare system”.
The clinicians must learn to make distinction between acute and chronic pain before embarking upon treatment. The skill of proper pain management lies in not in ability to perform difficult advanced blocks but in the determination of appropriate diagnosis & therapeutic modalities

The treatment of the acute, chronic & cancer pain is demanding & challenging. Effective pain management presents a significant challenge for physicians, other healthcare professionals, and their patients.
A problem arises when chronic pain feels like acute pain, is described to (and is accepted by) physicians and therapists as acute pain, and is then treated as acute pain. When this happens results are apt to be disappointing to both the patient and the physician and both may end up feeling quite frustrated. To both recover from, and to treat, chronic pain requires taking a different approach.
“Take two aspirins & go to bed” dictum of old days is over “What can’t be cured has to be endured” has changed with the role of the interventional pain specialist. Pain speciality It’s a “medical necessity”
There have been many advances in the understanding & usefulness of an intervention at right time in selective patients producing excellent results.

Our ultimate goal is to cure & care people suffering from pain, make them productive human beings for the society and increase their self esteem so that they can live life as normal individuals.
Interventional pain procedures scores over both medicine and surgery, as they do not have side effects like medicines. Surgeries for pain, have now limited indications, usually as a last resort.
The interventional pain procedures produce immediate pain relief, can be performed with ease by pain physicians without anesthesia as outpatient or daycare and adequate duration of pain relief obtained and suitable for surgically unfit & debilitated patients, procedure can be repeated safely if required.
In the absence of proper education among health care professionals and lack of awareness in the public mind in India, there is misuse of painkillers resulting in high incidence of complications like gastritis, kidney failure, and bone marrow depression.
The Indian health care scene has a curious mix of paradoxes. Advances in cardiovascular surgery or high-tech investigative facilities in India are on par with any advanced country, at least in some cities. Though skills, advanced equipments are available, still pain relief is not available to majority of its population. At least a million people in India suffer unrelieved cancer pain. The number of people suffering other chronic pain conditions is anyone’s guess. Paradoxically, India stands high chance to become the health destination for pain management for the world, by using interventional pain therapies and very effective traditional therapies unique to India.
With the advancement of technology and science, we have unveiled many aspects of the pain and its treatment. We have to work hard to spread the knowledge of interventional pain techniques. Our goal is to help people suffering from pain, make them productive human being for the society and increase their self esteem so that they can live life as normal individuals.
Unfortunately awareness about pain management among medical professionals is very limited. In contrast to USA and other developed countries Indian medical community is not aware of interventional pain management techniques which can be helpful for many patients suffering from intractable chronic pain.
Pain treatment is tailor-made & no single treatment fits all.
Under treatment of pain is a major public health concern. It is a silent epidemic, don’t let this happen to someone you love. Untreated pain destroys people’s lives. I have had patients come in who couldn’t work or sleep or play with their children. Good pain management gave them their lives back. It is cruel to deny people in pain access to effective pain treatment. People should not be suffering needlessly.
“Pain is real & treatable - There is no merit in suffering!”
----------------------------------------------
“Control pain before it controls you” as “Pain begets pain”
“Sweet is death that takes away pain” is true for cancer pain.
“Pain is more terrible master than death itself”
“For all the happiness man can gain, is not in pleasure but freedom from pain”.
“Pain has the thousand teeth”.
“You purchase pain with faulty lifestyle” “All pain is a punishment”



CONTROL PAIN BEFORE IT CONTROLS YOU !
FOR ADVANCED PAIN MANAGEMENT OF:-

CHRONIC INTRACTABLE PAIN SYNDROMES
BACK PAIN / LEG PAIN (DISCOGENIC/SPINAL CANAL STENOSIS)
FACET JOINT SYNDROME/SPINAL ARTHRITIS
SPINE (AXIAL) PAIN (CERVICAL/LUMBOSACRAL/THORACIC)
SACROILITIS / STRAIN & COCCYDYNIA
DISC DISEASES (HERNIA/PROLAPSE/RUPTURE/SLIPPED)
REDICULOPATHY / SCIATICA
NEURALGIC PAINS / PLEXOPATHIES
HERPES ZOSTER PAIN /NEURALGIA (PHN)
TRIGEMINAL / CRANIAL NEURALGIAS
SPASTIC CEREBRAL/SPINAL PALSY
REFLEX SYMPATHETIC DYSTROPHIES (RSD)
COMPLEX REGIONAL PAIN SYNDROMES (CRPS 1 & 2)
FAILED BACK SURGERY SYNDROMES (FBSS)
MUSCULOSKELETAL / MYOFASCIAL PAIN SYNDROMES
VASOSPASTIC ISCHEMIC PAINS
NEUROGENIC CLAUDICATION
CERVICOGENIC / TENSION/CLUSTER HEADACHES
POST SURGICAL / POST TRAUMATIC / SPORTS INJURY PAINS
CENTRAL PAIN STATES
FIBROMYALGIA
CANCER PAIN/ END OF LIFE PAIN / AIDS PAINS
CHRONIC VISCERAL / PELVIC PAIN SYNDROMES
FRACTURE SPINE (COMPRESSION # OF VERTEBRA)
OSTEOPOROSIS / METASTATIC / PAGET`S DISEASE BONE PAINS
HYPERHIDROSIS (WET HANDS/UNDERARMS/FEET)

REMEMBER: NO ONE DIES OF PAIN BUT MANY DIE IN PAIN
AND EVEN MORE LIVE WITH PAIN !

“HELP THEM”

NON SURGICAL TECHNIQUES OF SPECIALISED
FLUOROSCOPIC/ULTRASOUND/NERVE STIMULATOR/CT GUIDED
PERCUTANEOUS INTERVENTIONAL PROCEDURES
FOR DIAGNOSTIC/THERAPEUTIC/NEUROLYSIS OF:-

DIAGNOSTIC EPIDUROGRAPHY FOLLOWED BY
TRANSFORAMINAL / INTERLAMMINAR EPIDURAL MEDICATION AT
CERVICAL / THORACIC / LUMBAR / SACRAL / CAUDAL LEVELS
SELECTIVE NERVE ROOT SHEATH BLOCK (SNRB)
PROVOCATIVE DISCOGRAPHY & INTRADISCAL INTERVENTIONS
LUMBAR/CERVICOTHORACIC SYMPATHETIC BLOCKS / NEUROLYSIS
PERCUTANEOUS VERTEBROPLASTY (PVP)
FACET JOINT/ SACROILIAC JOINT / PIRIFORMIS BLOCKS
DECOMPRESSIVE NEUROPLASTY / EPIDURAL ADENOLYSIS
INTRATHECAL OPIATE/BACLOFEN PUMP IMPLANTS
SPINAL CORD STIMULATOR/NEUROMODULATION IMPLANTS
CRANIAL NERVES BLOCKS / NEUROABLATIONS
TRIGEMINAL GANGLIOLYSIS
SOMATIC NERVE / MYOFASCIAL / MYONEURAL BLOCKS
TRIGGER POINT INJECTIONS WITH STEROIDS/BOTOX/NEUROLYTICS
STELLATE/CELIAC PLEXUS/HYPOGASTRIC/IMPAR NEUROLYSIS
BOTOX CHEMODENERVATION
PROLOTHERAPY/MESOTHERAPY/INTRAMUSCULAR STIMULATION
INTERPLEURAL CATHETER /SPLANCHNIC BLOCKS
PARAVERTEBRAL / PSOAS COMPARTMENT BLOCKS
NERVE SHEATH & PLEXUS CATHETERISATION & MEDICATION
LASER LESSIONING / RADIOFREQUENCY (RF) NEUROABLATIONS
CONTACT:-
DR. NEERAJ JAIN M.D.
SENIOR CONSULTANT INTERVENTIONAL PAIN SPECIALIST
SPINE & PAIN CLINIC
98100 33800 (M) 27341685 (C)
,
SRI BALAJI ACTION MEDICAL INSTITUTE


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Jul01
POST PROSTATECTOMY INCONTINENCE
Stress urinary incontinence in men after prostate surgery is usually a result of intrinsic sphincter deficiency. Active conservative management with fluid restriction, medication management and pelvic floor exercises is indicated for the first 12 mths. If bothersome incontinence persists, urodynamic evaluation is indicated to assess detrusor storage function, contractility and sphincteric integrity. Standard surgical options include urethral bulking agents, artificial urinary sphincter (AUS) and male sling. Periurethral injection of bulking agent is satisfactory in only a minority of patients but AUS and male sling are the most common surgical treatment. AUS seems to have a higher success rate than male sling. AUS is indicated in men with hypocontactility of the detrusor as adequate detrusor contractility is needed to overcome the fixed resistance of the sling. However, infection, erosion, and revision rate for the male sling seem to be somewhat lower than that for the AUS .


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Jul01
Conquer Stress
Conquer
Stress


Doctor
Shriniwas
Kashalikar


The news on tv showing; significant increase in mental illness due to poverty, unemployment and cut throat competition; should be an eye opener for all of us in the world.

My books related to total stress management written about15 to 35 years ago and even my speech during my internship in miraj; had emphasized the socioeconomic causes of physical and mental illness and are more than validated by this news. My views were then; ridiculed, humiliated, neglected, suppressed and at best; appreciated with mere lip sympathy, wry smile and ice cold response of zero cooperation.

My views ; more than endorsed by this news and its corollary; insist that we can never succeed in total stress management; without participating in the socioeconomic, political and other issues influencing our lives. We may or may not join a political party or an organization, but we have to assert our conscience, enlightenment, objective consciousness that is. Innate core of true self; for successful total stress management; firmly. All those (so called spiritual leaders and so called stress management professionals and so called yoga teachers); who are trying to advocate “merely personal stress management” and all those (political leaders); who are trying to solve social problems; through their ad hoc, petty and or callous politics; are bound to fail miserably.

Thus; the number of so called spiritual leaders and political leaders; being exposed and brought to justice is bound to increase exponentially!

The maharashtra government (and probably many governments in the world) is adopting alcohol promotion policies which ensure mass suicide or even worse than suicide! We all; if we witness these steps of government passively; then suffer miserably and exponentially; due to being party to the sin of passing on this legacy to the posterity! But this will not happen!

Such policies; responsible for the suffering of generations after generations; would be averted by the rising global consciousness.

Namasmaran that is. Reorientation to cosmic consciousness has to be the goal, the purpose, the core and the basis of every policy including the rejection of alcohol production. But mere opposition to alcohol without channelizing our vitality to cosmic self through namasmaran; can lead to defeat, frustration and many socio psychiatric and socio-pathological evils!

Let us understand that we can not appreciate certain convictions, unless we have been sufficiently evolved and become reasonably objective. Thus if alcohol is our weakness, then we can not appreciate and support the opposition to alcohol production; even if it is destructive to us and the society! This is what causes innate conflicts and stress!

Conquering these conflicts and stress; is difficult but inevitable! So, let us not be desperate and violent to others and or to ourselves! Let us simply practice and propagate namasmaran, assert our convictions, and experience the inner and outer revolution and individual and global blossoming!

Many adjuvant measures can be useful in conquering from time to time and in different situations; but can never replace namasmaran!


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Jul01
TOTAL STRESS MANAGEMENT AND HOLISTIC MEDICINE
TOTAL
STRESS MANAGEMENT
AND
HOLISTIC
MEDICINE

DR.
SHRINIWAS KASHALIKAR


The Total Stress Management or Holistic Health incorporates blossoming of an individual and universe; and the various efforts in achieving this; include holistic perspective, accurate and appropriate policies and effective implementation at individual and global level in different fields of life; and these efforts in case of medicine; constitute holistic medicine.

The concept of holistic medicine emerges as a result of realization of the underlying unity, continuity and complementarity; amongst the apparently different disciplines of medicine (In fact it emerges from the realization of the universal unity, continuity and complementarity). This is emergence of SATVIKA JNAANA (Geeta 18.20).

It is usual for most of us to get stuck to the differences (in the study of different fields) as and when they strike our senses; and build our concepts; based on these isolated observations of ours. The knowledge and understanding of different fields or disciplines as separate disjointed or disconnected entities; is called RAJASA JNAANA (Geeta 18.21).

Those who either practice mixed or integrated medicine or are not averse to dialogue or advocate it, may fit in this category.

The third variety is ignorance about every other medical discipline and adamant adherence to any given medical discipline alone; is a state of darkness called TAMASA JNAANA (Geeta 18.22). Most of the warring factions from different medical disciplines; opposing the emergence of holistic medicine can fit in this category.

The word holistic is derived from the Greek word holos which literally means a) Taking in the whole of something b) Whole of organism is a more fruitful field of study than its parts or symptoms.

It can be stated for the sake of simplicity and further clarity that the holistic medicine is trans-religious (not religious or not non religious i.e. neither holy nor unholy), trans-national (neither national nor non-national/anti-national), trans-cultural (neither of a particular culture nor against any particular culture), trans-intellectual (neither bound in a particular intellectual framework nor opposed to a particular intellectual framework), trans-ideological (neither committed to a particular ideology nor opposed to a particular ideology) and trans-scientific (neither unscientific nor locked in rigid criteria of physical sciences)!

Study of holistic medicine constitutes efforts to understand, visualize and realize the multi-charactered, multifaceted, multidimensional and multi-layered complex nature of life (in addition to what is learnt in allopathy or what is learnt in any one discipline). The intention of the study is to comprehend the agreement, continuity and validity (or otherwise) of the concepts of different disciplines (allopathy, Ayurveda, SAANKHYA philosophy, homeopathy, yoga, Chinese medicine etc.), which emerge and get evolved from different levels of consciousness; of differently constituted individuals; in different regions; at different time periods; with different backgrounds.

The approach of holistic medicine; can not be classified merely; as eclectic, analytical, synthetic or reductionist etc. The holistic approach embodies all these as means to “see” the unity and continuity in different phenomena.

The holistic medicine is therefore not a new system or a new discipline of medicine. It is a way to see things as they are rather than how they appear; and thereby preserve and promote health and healing.

Studying holistic medicine; simultaneously makes us aware of possibilities as well as limitations. For example understanding the ayurvedic concepts such as DOSHA, DHATU, MALA, their balance, their imbalance, the concept of PRAKRUTI i.e. constitution etc. with holistic approach, add new dimension to the knowledge of the student of physiology as well as to the diagnostic skills of a clinician from the discipline of allopathy. Understanding of the concepts of panchakarma, naturopathy, yoga etc. with holistic approach makes the treatment also more effective because several different modalities and remedies in the repertoire act at different levels or different points and complementarily. But study of holistic medicine; also makes us aware of the importance of the analytical approach inherent to allopathy. This is why a student of holistic medicine is unprejudiced, open and objective.

Besides; the holistic understanding of human existence (which is fundamental to the study of holistic medicine), gives us insight into the enormous healing powers; inside patient, in the environment; and helps us to help him/her to use those powers beneficially. This is a great benefit in terms of empowerment of the clinician as well as the patient. Thus; holistic medicine relieves health care providers such as doctors and paramedics and all others; from the unhealthy patronizing and condescending attitude and makes us aware of our own limitations, i.e. gives us knowledge of our ignorance! It gives us the courage to see our ignorance and admit it. It imparts intellectual honesty to admit the ignorance hidden under the Greek, Latin, Sanskrit or other esoteric/mystifying terms, characteristic to many branches of science in general and medicine in particular. Take for example hysteria. We do not know any physiological mechanisms underlying this condition. But the ignorance is hidden under the term. Another example is that dreams, thoughts, emotions etc. The ignorance about the physical dimensions of dreams, thoughts, emotions etc, even as we can not dispute or disprove their existence; is hidden under several terms! Holistic medicine discourages and disapproves knowingly or unknowingly practiced hypocrisy and imparts humility.

Some more examples from the disciplines of medicine are as follows. Holistic approach enables us to see the limitations intrinsic to the concept of standardization of weight, height and possible errors in interpretation of biochemical parameters and calculation of regimentalized doses of drugs due to the lack of due consideration to variations in the constitutions.

Holistic medicine cautions us against indiscriminate use of ayurvedic drugs without due consideration to the variation in the quality, nature, source etc. of the ingredients of the drug as well as the constitution of the patient and the type of climate.

Holistic medicine gives us insight into the possible mechanism of the action of homeopathic drugs on the one hand and cautions about the ambiguity in the method of diagnosis arising out of subjective factors related to the doctor as well as the patient, on the other. Holistic medicine indicates the complementarity between the actions of different remedies from different disciplines of medicine and improves the healing process.

Holistic medicine reveals to us the possibility of “cosmic homeostasis” on the one hand while simultaneously exposing the possible fallibility; intrinsic to the tall claims and sectarian practice of distance healing, gemology, astrology, numerology etc. which have different approaches and interpretations, without sufficiently convincing reasons; and which oppose the science blindly.

Beside all above, implication of the holistic medicine is; its readiness to change and accommodate new ideas, i.e. not getting shackled in dogmas of any kind.

But possibly the most important implication is development of proper perspective about the health and healing, which would help in development of proper policies of services, education, research, production in the field of mainstream medical care, education, research and coordination of all these; with policies in the other fields (influencing the health directly and indirectly) such as education, industry, environment, agriculture etc.

From practical point of view, syllabus, practice and research of holistic medicine; in every healing center besides all hospitals and medical colleges; should incorporate; NAMASMARAN, prayers, water therapy, proper food (diet), mud packing, massage, yoga, music, colors, aroma and other appropriate healing methods (so much recommended by Mahatma Gandhi)! Individual, national and universal blossoming is impossible without holistic medicine!

DR. SHRINIWAS KASHALIKAR


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Jul01
AGING AND TOTAL STRESS MANAGEMENT
AGING
AND
TOTAL
STRESS MANAGEMENT


DR. SHRINIWAS
KASHALIKAR
Even though aging begins right from conception; it usually refers to the changes in us after the age of forty to fifty years.

Thus; aging undoubtedly leads to variable but distinct reduction in physical capacity and performance. The degree of consciously perceived stress in the form of unpleasant feeling of insecurity, anxiety, worry, tension, depression resulting from relative handicap is obviously more during these years.

Before we consider the way of Total Stress Management while aging, let us first consider in brief; the concept of Total Stress Management (Holistic Health)!

Total Stress Management or Holistic health is nothing else but ongoing progress in perceptions, feelings and actions; with increasing accuracy, appropriateness, precision; and pleasure, power, prosperity and profundity. Perception, feelings and actions are also expressed by terms Cognition, Affect and Conation (Productivity and Creativity); respectively.
A] Cognition
In short, cognition means processing [appraisal] of a huge variety of sensations impinging on us. We can appreciate the importance of this faculty if we consider the two important facts viz. 24 hours of the day and twelve months of the year, every one of us gets sensory inputs in the form of physical, instinctual, emotional and intellectual stimuli, which may be painful or pleasurable in the form of a variety of personal, familial, social, national and international events. Cognition involves sensing, interpreting, memorizing, questioning, pattern finding, analyzing, correlating, synthesizing, contemplating, understanding, appreciating and hypothesizing on the basis of this information input.
2] Affect
Affect means the effect of the variety of stimuli which, may impinge on us. The affect is in a way, “sandwiched” between; cognition or perception of stimuli and the conation or response.

In general it involves the activity of various parts of nervous, endocrine and metabolic changes. The affect is usually experienced as a] confidence, enthusiasm, excitement, pleasure, happiness, love, attraction, patience, comfort etc. or b] sadness, jealousy, hatred, depression, inhibition, diffidence, loneliness, listlessness, impatience, discomfort etc.
3] Conation or action i.e. response
Conation is the response of an individual. This can be in the form of speaking, writing, singing, painting, dancing, fighting, and other interactions usually referred to as behavior.

In Hindu tradition this response was aimed at fulfillment of life and the precept for the life time activity was called PURUSHARTHA. There were four sequential components; of PURUSHARTHA viz.; DHARMA, ARTHA, KAAMA and MOKSHA.

DHARMA refers to accuracy in perception, affect and conation. This leads to ARTHA i.e. acquisition of material gains, followed by KAAMA i.e. satisfaction of the mundane desires, which are not against the principles of individual and universal blossoming) and MOKASHA i.e. liberation from all sorts of bondages.
In short; Total Stress Management or holistic health; refers to ever increasing and appropriate satisfaction of physical, instinctual, emotional, intellectual needs and fulfillment and happiness arising from it.

Total Stress Management or Holistic Health while Aging:

By the word aging we generally think of; merely an unpleasant process associated with dysfunction and disability. We think of a phenomenon full of dependence and helplessness. It seems to indicate only cumulative wear and tear due to micro insults and time dependent programmed loss of structure and function. It seems to imply physical, psychological, intellectual and social incapacitation. It seems to involve choking of charm, routing of romance, decay of dreams, annihilation of aspirations and end of new beginnings. It seems to be an entity that signals us to wind up every thing and get ready to quit this world - the world; that we so much long to live in.

But is this entirely true?

Let us study the process of aging and find out!

But for that; we have to first distinguish the handicap or dysfunction that results from the diseases; and the changes resulting from the natural process of aging that takes place in the absence of diseases.

We can appreciate that such distinction is quite difficult. Most of us suffer from ailments such as infections, malignancies, diabetes, IHD, as well as environmental onslaughts in the form of ultraviolet radiation, heat, cold, pollution, food additives, allergic substances, physical and chemical injuries etc apart from psychological inflictions!

But still the changes, which take place after forty and fifty; in the absence a history of gross or major diseases or accidents; roughly represents the true aging and is generally attributed to two basic facts

1) Genetic program, which decides the range of the longevity of life for a specific species and determines the time dependent loss in structure and function characterizing senescence and death and 2) Accumulation of injuries or micro insults:

Since very little is understood in this respect; there are many theories based on these two tenets meant to explain aging. Since they focus on a specific change, they are inadequate in isolation; but together they do give us some insight into the process of aging.

THEORIES OF AGING:

A] The Error Catastrophe Theory:
Random increase in errors of protein synthesis i.e. defects in the processes involved in protein synthesis called transcription and translation. But aging processes seem to be posttranslational (i.e. after the proteins are completely synthesized) modifications. Further, in senescent cells accumulation of misspelled proteins is not found and induction of synthesis of erroneous proteins experimentally does not give rise to ageing. Thus there is possibility of that errors are not causes but merely coexisting with aging processes.

B] Somatic mutation theory:
This suggests that there is age associated increase in chromosomal aberration. This is suggested to give rise to progressive increase in inefficient cells leading to organ dysfunction.

C] Free radical theory:
Accumulation of metabolic waste products and radical mediated cell damage e.g. hydroxy peroxide, aldehydes and ketones, superoxide radical, singlet oxygen and hydrogen peroxide. If this were so, we would expect lipid peroxidation at cellular level, which is not demonstrated in aging. Further, the antioxidants which we expect to delay aging are not proved to do so!

D] Ionizing radiations and such other environmental factors may cause cell injury. This could be so; but the cause and effect relationship and the quantitative aspects; are not yet demonstrated to cause aging by themselves!

E] Cellular dysfunction in tissues such as CNS, endocrine and immune system; influences other systems and causes aging! Thus decreased synthesis, increased breakdown, decreased receptor number, decreased Hormone-Receptor (HR) combination, decrease in HR internalization etc may be responsible for aging.

These are merely physiological interactions (associated with aging) amongst tissues; and can not be called mechanisms or causes of aging.

F] Sedentary jobs, late night parties, noise, crowding, stress of highly competitive life, uncertainty of socio-political surroundings, consistent and protracted denial of the recognition and appreciation in life, habits such as excessive smoking, lack of enjoyable job, lack of promotions and incentives in jobs etc. and the plethora of stressors either not thought of or not given due importance and hence not mentioned in the text books; immensely expedite or aggravate (though do not constitute the basic mechanisms or causes as such) the aging process; and are described; in my books viz. “Stress: Understanding and Management” and Conceptual Stress: Understanding and Management”.


CHANGES DURING AGEING PROCESS

Overall changes in the body are loss and graying of hair starting with the temporal hair (side buns), drying and wrinkling of skin, loss of teeth, decrease in reaction time, decrease in the height, increase in the length of nose, increase in the length of ears, decrease in the circumference of neck, decrease in the circumference of thighs, osteoporosis, bending of the vertebral column causing kyphotic deformity, reduction in the periorbital fat causing sinking of the eyes etc. Broadly speaking, maximum capacity, tolerance, peak performance and reserve are reduced.
The details of the changes can be enumerated as follows.

Matrix:
Collagen becomes stable, more rigid, more insoluble due to increase in its degradation. In addition there are changes in proteoglycans and plasma proteins. This is due to damage due cross linking, less formation of collagen and reduction in the elastin. Fascia, tendons, ligaments, bones, joints, and peripheral vascular disease become rigid. Skin becomes dehydrated, devoid of subcutaneous fact and less elastic thus skin becomes wrinkled, dry, pale due to reduction in capillary bed, and becomes more susceptible to injury.

Blood:
Red bone marrow is replaced by yellow bone marrow in the long bones first, flat bones and then vertebrae. Physiological reserve capacity for erythropoiesis and leucopoiesis (Formation of red blood cells and white blood cells); is reduced.

Gastrointestinal tract (GIT):
*Enamel, dentin and cement of teeth show decline. There is loss of teeth due to caries, periodontal infection and reduced masticatory efficiency.
*Weakness of cricopharyngeus (Muscle of swallowing), reduction in pressure gradient and inability to relax the lower esophageal sphincter cause dysphagia (difficulty in swallowing).
*Age related atrophy of inner lining of stomach called mucosa causing achlorhydria (absence of digestive acid in stomach).
*Pancreatic lipase (fat digesting enzyme secreted by pancreas) is reduced causing streatorrhoea (presence of fat in the stools).
*Motility of GIT is reduced: Hence there is tendency towards constipation. In Ayurveda this is categorized under VAATA VRIDDHI.
*Intestinal lactase activity is reduced and villi are reduced and absorption is reduced.
*Liver cells reduce in number fibrous tissue increases in the liver and size of liver cells increases.
Protein synthesis and microsomal mixed oxidase activity required for metabolism of drugs and steroids; become less. Thus functions are reduced but since the reserve of liver is great; the liver function tests are in normal limit.

The immune system:
There is decrease in the T cell activity, Antibody (AB) production; but increase in the presence of auto anti bodies.
The auto-antibodies are increased due to reaction with the antigens (which were previously recognized as “self” and not reacted with)! This is called reduced tolerance to “self” antigens.

There is susceptibility to infections.

Since immunological - surveillance is believed to eliminate neoplastic cells (cancer cells); there is higher incidence of cancer.

Following stress of bereavement; there is steep decline in cell mediated immunity (T cells) and this is one of the causes of infections leading to the death that follows the death of spouse or any other near and dear one.

Reproductive system:
The hormonal secretion reduces and there is stoppage of ova formation, ovulation in females and there is gradual reduction in the spermatogenesis (formation of sperms) causing reduction in the sperm count in males.

Females show a distinct and identifiable change in the form of menopause; where as such change is not distinct in males.

There is reduction in sexual performance in terms of number masturbations and number of intercourses in a given time and reduction in the functions such erection, ejaculation and the climax. The infatuation about sex may be increased and provoked by pornographic and or sexually romantic atmosphere even as the sexual performance is dwindled.

Central nervous system and special senses:
There is atrophy of the brain and neuronal loss associated with accumulation of lipofuscin and loss of synapses and dendrites. Cholinergic deficit is demonstrated in Alzheimer's disease and Dopamine defect is demonstrated in Parkinson's disease. But, milder form of cholinergic deficit may be responsible for commoner forms of senile dementia and milder form dopaminergic deficit may be responsible for milder form of hypo-kinesia seen in old age.

There is deficit in autonomic responses leading to postural hypo-tension and impairment of temperature regulation.

There is difficulty in getting sleep as well as there is tendency to wake up during night and waking up early.

There is development of Presbyopia (age related difficulty in focusing on the near object), cataract, rise in intraocular pressure; Presbyacusis (age related difficulty in understanding speech and localization of sound) decline in perception of smell and taste.

Endocrine system:
There is decrease in the functioning of sympatho-adrenal axis and there is reduced tolerance to stress. In other words, there is inappropriate production of adrenaline, noradrenalin, cortisol etc.

Cardiovascular system:
Aging is associated with atherosclerosis. But even in those without atherosclerosis; there is still reduction in the elasticity of aorta (indicating overall changes in connective tissue); leading to increase in systolic and pulse pressure; but not in diastolic pressure. In addition; there is also atherosclerosis, atrophy of myocardium, accumulation of lipofuscin, fibrosis, deposits of amyloid, diminish in contractility relaxability, decrease in ventricular compliance, stenosis of aortic and incompetence of mitral valves, reduction in pacemaker cells, responses to sympathetic as well as parasympathetic stimulation also reduce (this causes postural hypotension).
Maximal Heart Rate during exercise is reduced in aged but cardiac output is maintained by increasing stroke output.

Respiratory System:
The alveoli (the air pockets in the lungs) become flatter and narrower and ducts enlarge. Alveolar walls become thin, capillaries decrease in number causing reduction in diffusion, surface area decreases by 4 % every decade after the age of 30 and the pulmonary blood vessels show age related increase in wall thickness.

Functionally there is decrease in total and timed vital capacity, increase in residual volume, due to reduced elastin lung compliance increases (degree of expansibility) but compliance of the total respiratory system decreases due rigidity of chest wall after the age of 60 years. Due to loss of elastic recoil the pressure which has to be built during expiration from the alveoli; so that air from alveoli forces open the airways, is decreased. Due to this there is tendency of the airways to collapse. This tendency to collapse; increases during expiration when expiration must become active. The response to hypoxia and hypocapnia (reduced carbon dioxide) are reduced.

Thus ventilation, diffusion and regulation are all impaired in elderly individuals.

Muscles:
There is atrophy, reduction in contractility, decrease in tone, hernia and rupture of inter-vertebral disc etc.

Excretory system:
As a result of aging; the kidneys reduce in size and their blood flow and rate of formation of urine reduces by 10 % per decade after 30, nephrons (urine forming tubules) and their secretory and absorptive functions; reduce and fibrous tissue increases. Kidney vessels show age related changes irrespective of hypertension (high blood pressure).

It has been hypothesized that due to high protein diet there may high solute load on the renal capillaries leading to chronic dilatation of the capillaries leading to extravasation of macromolecules in renal glomeruli leading to mesangial reaction causing renal damage.

PSYCHOLOGICAL CHANGES
Frustration, depression, fear, anxiety, insecurity, loneliness, vacuum, dejection, self pity, sadness are some of the hallmarks of old age. This is because; 1. With aging there is increasing restriction on the kind of accustomed enjoyments (e.g. sexual); and this can lead to frustration or depression. 2. The realization of the increased chances of death; (due to observation of the deaths of the contemporaries); causes alarm, concern, anxiety and excessive fear of death, diseases and debility. 3. Due to lack of job after retirement or physical inability there is always a sense of insecurity. 4. Lack of the children's company due to their being increasingly independent gives a feeling of unwantedness and loneliness, especially due to children going abroad or away from home for their jobs. 5. Since most of the people of younger age groups; have their own pre-occupations we the elderly are left out. 6. Due to generation gap; the ideas, choice, preferences and other areas of interests differ and hence the elderly are cut off from younger generation. This distance gradually increases with advancing age and leads to vacuum, dejection, self pity and sadness. Thus overall we tend to become increasingly melancholic in old age.

ECONOMIC CHANGES
The aging almost always associated with reduced income and increasing economic dependence on the others. The medical expenses also swell!

SPIRITUAL CHANGES
We begin to visit temples and participate in SATSANG. This is because we want a certain kind of solace which we do not get from day to day life and routine activities. This is also to fill the vacuum created due to retirement, and to get company of those who sail in the same boat!

When we are aging; we become somewhat disinterested and indifferent towards life. But this is not detached attitude described in Geeta. We get detached because; we cannot participate or oppose the activities of young generation! Thus; this is actually reluctant acceptance of defeat!

Sometimes we develop ascetic thoughts due to losing interest in the routine life because we are tired of responsibilities and dynamism required; for a job or a profession. Even as this engenders reduction in income; it is not a spiritually oriented selflessness and sacrifice. It is only fallout of mental apathy.

Sometimes we lose interest in the surroundings due to decreasing sensory perception and decreased mobility. We become shy about our deficiency. So we avoid socialization. Gradually we become increasingly self centered and selfish. We become over-concerned about ourselves and less sensitive to others' problems. We become more rigid, adamant and at times obstinate; in an attempt to assert ourselves; and become unreasonable and erratic.

The courage, alertness, enthusiasm and other physical and mental faculties which are extremely important to undertake spiritual pursuit i.e. growth of consciousness are considerably diminished in old age; unless the spiritual quest has been integral part of us from childhood.

However having said all this; the impression, which we get from the foregoing, is quite inadequate and therefore wrong, dangerously pessimistic and depressing. The aging, as made out to be by merely observing certain physical or psychological changes; without realizing that there is a vast difference between our aging and that of the animals; creates fear about aging. As a result; instead of helping ourselves and others; we expedite the process of aging and its ill effects! We can refer to these conditions; with new terms viz. gerontophobia, and genrontoneurosis.

Let us realize that; while aging, a person accumulates not merely micro insults and injuries but simultaneously accumulates a variety of pleasant experiences (e.g. romance) and fulfillment, satisfaction, and contentment due to achievements in life! Even in the lesser fortunate ones; aging is associated with the happiness of having procreated, reared, pampered, and played with the children and grand children and the satisfaction living and not dying prematurely!

Further it has to be realized that while aging we gradually learn the inevitable nature of aging and death; and hence gradually learns to accept them uncomplainingly and gracefully.

Age is respected in Indian culture. Thus age brings (though this is not a universal truth) extra care, respect, services and comforts in preference to the younger lot.

Philosophically speaking; let us clearly and definitely understand and appreciate without any ambiguity that aging is not merely becoming old, but actually growing and maturing! Aging is actually; the culmination of our passage (through the body) full of wonderful learning and blossoming experiences of merging with our true self through NAMASMARAN!

BUT WHAT IS NAMASMARAN?

(The following explanation is given by Dr. Shriniwas Kashalikar in response to a clarification sought by Dr. Suhas Mhetre; for the benefit all those, who are not conversant with the concept and practice of NAMASMARAN)

Namasmaran means; remembering the name of God, Guru, great souls; such as prophets and holy objects such as planets and stars. It may be remembered silently, loudly, along with music, dance, along with breathing, in group or alone, either with counting by rosary (called SMARANI or JAPAMALA) or without counting. The traditions vary from region to region and from religion to religion.

However the universal principle underlying NAMASMARAN is to reorient your physiological being with your true self. In fact while reorienting with true self you aim to establish and strengthen the bond or connection; between; your physiological being; with your true self. You aim at reunification with yourself!

Since remembering your true self is the pinnacle of or culmination of individual consciousness, and individual consciousness is the culmination of every activity in life, remembering any name of God or Guru (any symbol of your true self) is equivalent to opening the final common pathway for the individual consciousness associated with every possible activity to get funneled into or unified with objective or cosmic consciousness.

Thus NAMASMARAN is in fact the YOGA of YOGA in the sense that it is the culmination of consciousness associated with every possible procedure and technique in the yoga that you are familiar with. It is the YOGA of YOGA because it is the culmination of consciousness associated with all the activities in the universe, which it encompasses as well! It is YOGA of YOGA because everybody in the world irrespective of his/her tradition and the beliefs; would eventually, ultimately and naturally reach it it in the process of liberation. Even so called non believers also would not “miss” the “benefit of remembering the true self through one symbol or another”!

Just as NAMASMARAN is YOGA of YOGA it is meditation of meditation also! It is the natural and ultimate climax of every form of meditation.

These facts however have to be realized with persistent practice of NAMSMARAN and not blindly believed or blindly disbelieved with casual approach!

In short NAMSMARAN is super-bounty of cosmic consciousness for every individual to realize it (cosmic consciousness)! This is truly a super-bounty because a person, who experiences it, rises above mercenary, commercial and even professional and charity planes and manifest super-transactions in his or her life!

These are just few observations to give rough idea about what is NAMASMARAN.

NAMASMARAN is an ocean of bliss. Its true meaning is beyond description in words.


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