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Jul18
Homeopathy Cures allergy and its Complications
It is difficult to distinguish between allergy symptoms allergic rhinitis and sinusitis. This is no small problem. Of all the chronic diseases from which we suffer, allergic rhinitis is the most common. Approximately 30 million Indian or 15% of the Indian, population suffer from allergic rhinitis. Sinusitis, on the other hand, is one of the most common complications of allergic rhinitis. The problem with differentiating these two conditions occurs, because allergic rhinitis and sinusitis may both present with the same symptoms, such as fatigue, runny nose, chronic cough, congestion, post nasal drainage, headaches, facial or teeth pain, loss of taste or smell, and difficulty sleeping. Asthma, the other major complication of allergic rhinitis, is a lower airway lung disease that may present with cough, shortness of breath, and chest tightness, and in some studies, up to 40% of patients with allergies, have asthma.
Think then of a triangle: with allergic rhinitis on the left, causing sinusitis on the right, and both conditions causing asthma on the bottom. All three conditions can occur separately, but are closely interconnected. Remember that sinuses are simply empty cavities that surround the eyes. Air must be present in the sinuses to allow the linings of the sinuses to breathe and this is accomplished via small openings from the sinuses into the nasal passages. These openings also allow mucous from the sinuses to naturally drain into the nasal passages. If anything causes a blockage of the openings, the lack of air causes linings to use up the surrounding air supply, and like a vacuum, the resulting negative pressure will draw fluid out of the sinus linings. Fluid may then collect and fill the sinuses, which allows for bacteria to grow and cause infections. This can lead to facial pain, infected post nasal drainage and headaches. With increasing inflammation and thickening of the sinus linings, swollen tissue may round up and form nasal polyps that may cause and lead to loss of taste and smell. Allergic rhinitis and common viral colds are the leading causes of sinusitis, and the history and physical examination will help your provider distinguish the two conditions. Allergic rhinitis may be seasonal, lasting weeks, months or even year round, and is caused by pollen, dust mites. Fever and discolored nasal drainage are uncommon, unless sinusitis is also present. Conversely, typical viral colds last 3-7 days, so any fever, discolored drainage, sore throat, headache or fatigue lasting longer that 7 days is very unlikely to be a simple viral cold, and is most probably sinusitis. On physical examination, patients with allergic rhinitis and sinusitis may both have dark circles under the eyes (shiners), swollen, pale nasal tissue, congestion and discharge. Patients with sinusitis, however, may also have discolored discharge. Studies have shown that greater than 50-75% of allergic adults and children with asthma have abnormal sinus, and asthmatic symptoms did not improve until the sinusitis is treated completely.
ALLERGIC RHINITIS
Most patients 10-20% of the population with sneezing, congestion, runny and itchy nose rhinitis, postnasal drip and itchy, red eyes during spring and fall have allergies to seasonal pollens. A high percentage of allergic individuals will be children. Whether someone will develop

Allergies depends on two factors: (1) Hereditary - Is there a family history of allergy?
(2) Environmental- Is the individual old enough and been exposed to enough pollen? Symptoms due to allergies may be severe enough to cause a loss of time from work and school.

Interestingly, a percentage of patients with classic symptoms will be absolutely and unequivocally negative on skin testing. Allergy injections are not indicated and not possible, because these patients are not allergic. And yet patients are just as symptomatic, and just as miserable as the rest of us. How is this possible and what treatment is available?
Definition and Pathophysiology
The diagnosis of rhinitis without positive skin tests is divided into two subgroups. One subgroup, non-allergic rhinitis with eosinophilia, presents with allergy symptoms in addition to conditions such as nasal polyps and nasal eosinophilia, asthma and frequently sinusitis. The other subgroup, vasomotor rhinitis, presents with symptoms, especially congestion, but lacks other associated conditions.

The nasal mucosal lining has a rich blood supply that is under the control of the nervous system called the autonomic nervous system. Nonspecific stimuli such as rapid changes in weather, temperature and humidity, drafts, exposure to chemicals, odors, perfumes, smoke and dust, emotions or stress may increase blood flow to tissue, resulting in swelling, congestion and rhinitis. A significantly deviated septum may induce changes in the mucosa, worsen the non-allergic or vasomotor rhinitis and cause more nasal congestion and drainage. Hormonal changes that occur with pregnancy, menstruation, menopause, hypothyroidism and oral contraceptives may cause symptoms of chronic non-allergic rhinitis.
Clinical Features
Patients complain of chronic nasal congestion, rhinitis, postnasal drip and sneezing. Congestion and blockage may alternate from side to side and are usually constant, though seasonal weather changes may trigger symptoms that mimic dust allergies. Symptoms may be worse upon awakening in the morning. Examination reveals marked pink or pale nasal swelling obstruction and thick nasal secretions. In all cases, skin tests are negative. Patients with non-allergic but not vasomotor rhinitis will have eosinophils present in nasal secretions and frequently nasal polyps complicating the obstruction.
SINUSITIS
Sinusitis
Sinusitis is an infection or inflammation of sinuses. Sinuses are the air-filled pockets or spaces found in the bones of face, around eyes and nose. They produce mucus, which, under normal circumstances, drains into the nose. Normally the sinuses produce about 1.5 litres of mucus a day and the quantity increases during allergy, inflammation and infection and this also changes the character of the mucus. Infection of sinuses is one of the common health care complaints.

Pathology
Sinusitis occurs when the mucus-producing lining of sinuses become inflamed and block the opening of the sinuses. Due to this, foreign material cannot get out, oxygen levels drop within the sinus and bacteria in the nasal cavity slither into the sinuses causing the sinus walls to swell and fill with pus. If the infection does not subside, the body sends in disease-fighting cells to kill the bacteria, which in turn can do considerable damage to the sinus walls. These defender cells can damage the cilia, the hair-like structure in the sinuses that help expel foreign matter. In addition, scarring can be caused which can result in the formation of sores.
Causes of Sinusitis
Infection due to bacteria, virus, fungi
Allergy: Most commonest causes are dust, animal dander, smoke, food and pollutants
Upper respiratory tract infection such as common cold or flu
Nasal polyps
Nasal Septum deviation
Chronic tonsillitis and adenoiditis
Climatic factors like sudden temperature changes
Swimming in infected water
Low immunity
Dental causes like an abscessed or badly decayed tooth, following dental treatment
Diseases like diabetes and HIV can create a predisposition to sinusitis
Symptoms of sinusitis
Nasal congestion leading to nasal obstruction, difficulty breathing through the nose
Thick nasal discharge (may be yellowish or greenish in colour in case of infection)
Sensation of fullness in the face
Sensation of pressure behind the eyes
Postnasal drip
Cheeks feel tender and pain may be similar to toothache in upper jaw
Mild fever and headache over one or both eyes (if frontal sinuses are affected)
Headache is usually worse in the mornings and made sharper by bending forwards
Sore throat
Foul smell in nose
Nasal sounding speech
Possibly, pus-like nasal discharge
Dry tickling cough
Tiredness
Asthmatic Attack
In the initial stage there is an asthmatic aura sometimes sneezing, flatulence, Drowsiness or restlessness irritability will be present. There can be a dry cough along with wheezing breathlessness these are some of the symptoms before the actual asthmatic attack.
Sense of oppression in the chest suddenly in the middle of the night is experienced.
There is a sense of suffocation and the patient leans forward fighting for his breath; or he may go to the open window to relieve the suffocation.
Anxiety, perspiration, cold extremities and cyanosis might be present.
Wheezing is present and can be heard from a distant.
In severe airways obstruction airflow maybe so reduced that the chest is almost silent on auscultation.
Inspiration is short and high pitched while the expiration is prolonged. On auscultation there are plenty of rhonchi and rales heard.
Termination is spontaneous or due to medication. As the bronchial spasm is less the patient is able to breathe and he can also cough which brings out viscid sputum which relieves him.
The duration of the attack varies from a few minutes to hours. The attacks can last for many hours in paroxysms this state is known as Status asthmaticus. In this state the patient has to be admitted to the hospital so that he can be supplied with oxygen and other auxiliary methods of treatment
For many patients with asthma, the concern that this “reversible” though serious, potentially life-threatening persistent lung disease may progress into emphysema, is real and worrisome. After all, asthma along with emphysema and chronic bronchitis, the latter two conditions known as Chronic Obstructive Pulmonary Diseases (COPD), all have inflammation with airway narrowing, mucus production and airway obstruction. Homeopathy Management

Suppression of colds by high doses of conventional medicine leads to recurrent attacks. When you use a groom to clean your room, do you push all the dust in a corner of the room or collect it and throw away? It is a common sense that if you push to the corner of the room, in due course the dust will spread in the entire room again and make it dirtier. Same is the case with the disease affecting your body. If you suppress the disease, where will it go? It will remain in dormant state inside the body and express itself again when the body meets any of the allergic triggers. The homeopathic medicines however through the principle of “like cures like” stimulate the vital force and immunity in order to enhance the body’s capacity to repel further allergies and infections. The constitutional medicines that are found by considering the physical, mental, and emotional aspects of an individual can only lead him on the road of permanent recovery from those allergic spells. Not only these medicines cater the problem of allergy but also impart great health on all planes, as it treats the patient as a whole and not just his disease.


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Jun29
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Jun24
Bhargava R, Kumar P, Prakash A, Chaudhary KP. Estimation of mean ND: Yag laser capsulotomy energy levels for membranous and fibrous posterior capsular opacification. Nepal J Ophthalmol. 2012 Jan-Jun;4(1):108-13. doi: 10.3126/nepjoph.v4i1.5861. PubMed PMID
Abstract
INTRODUCTION:
Posterior capsule opacification (PCO) is a visually-disabling complication of cataract surgery.
OBJECTIVE:
To estimate energy levels for capsulotomy in various subtypes of PCO (membranous, fibrous and fibro-membranous).
MATERIALS AND METHODS:
A total of 215 patients with PCO were randomly selected and evaluated for Nd: Yag laser capsulotomy, after a quiet post-operative course of 3 months.The ocular area was arbitrarily divided into three zones: YAG zone (3mm), Optical zone (6mm) and the peripheral zone (12mm). A colour code was assigned to the subtype of PCO in these zones: fibrous green and membranous blue. The type of PCO in each quadrant of YAG zone was estimated in percentage.
RESULTS:
The statistic mean values of initial energy levels were 1.80 mJ for membranous PCO, 3.17 mJ for fibrous PCO and 2.73 mJ for fibro-membranous PCO. The mean summated energy levels for membranous PCO was 22.80 mJ for membranous PCO, 80.06 mJ for fibrous PCO and 80.48 mJ for fibro-membranous type.
CONCLUSION:
Colour coding is extremely helpful for quantification of the type of PCO and in deciding the initial energy level necessary to create capsulotomy. Fibro-membranous PCO required more summated energy despite a lower starting energy. Therefore, we recommend firing the initial shot in fibrous portion in case of fibrous-membranous type of PCO.


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Jun24
Bhargava R, Kumar P, Phogat H, Chaudhary KP. Neodymium-yttrium aluminium garnet laser capsulotomy energy levels for posterior capsule opacification. J Ophthalmic Vis Res. 2015 Jan-Mar;10(1):37-42. doi: 10.4103/2008-322X.156101. PubMed PMID: 26005551; PubM
Abstract
PURPOSE:
To study factors affecting laser energy levels required for neodymium: yttrium aluminium garnet (Nd: YAG) laser capsulotomy and to evaluate whether any correlation exists between applied laser energy levels and complications.
METHODS:
The present study examined 474 consecutive patients for a number of factors including age, type of posterior capsule opacification (PCO), material and fixation of intraocular lens (IOL) and complication rates, versus energy levels used for Nd: YAG laser capsulotomy.
RESULTS:
Mean patient age was 55.6 ± 8.7 years and mean follow up period was 22.9 ± 4.5 months. IOL biomaterial (KW ANOVA; P = 0.173) and patient's age (P = 0.246) did not significantly influence total laser energy requirement for capsulotomy. However, total laser energy levels were significantly higher (KW ANOVA; P < 0.001) with fibro-membranous and fibrous subtypes of PCO. Complications such as IOL pitting, intraocular pressure (IOP) elevation, uveitis, retinal detachment (RD) and cystoid macular edema (CME) were significantly more common when higher energy levels was used. The mean total energy in patients with RD was 77.7 ± 17.7 mJ as compared to 43.4 ± 26.9 mJ in the rest of the cohort. RD was more common in patients with higher axial length [n = 7 (63%)] (P < 0.001).
CONCLUSION:
Type of PCO significantly influenced laser energy levels required for capsulotomy, whereas IOL biomaterial and fixation did not. Complications such as IOL pitting, uveitis, IOP elevation, RD and CME was significantly more common when total laser energy was higher. It is recommended that the lowest possible single pulse laser energy be used for capsulotomy to minimize complications.
KEYWORDS:
Intraocular Lens; Laser Capsulotomy; Posterior Capsule Opacification


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Jun24
Bhargava R, Kumar P, Sharma SK, Sharma S, Mehra N, Mishra A. Peeling and aspiration of elschnig pearls! An effective alternative to Nd:YAG laser capsulotomy! Indian J Ophthalmol. 2013 Sep;61(9):518-20. doi: 10.4103/0301-4738.119449. PubMed PMID: 24104714;
Abstract
To evaluate the efficacy of peeling and aspiration of Elschnig pearls. Retrospective study in a medical college hospital. Records of 217 eyes which underwent surgical peeling and aspiration for membranous PCO between 2006 and 2009, was reviewed. Peeling and aspiration was fashioned with a blunt tipped 20G cannula after stabilizing anterior chamber with anterior chamber maintainer. Post-operative vision and complications were analyzed. Mc Nemar and Chi square tests. The mean age was 56.84 years. 85.71% patients achieved best corrected visual acuity (BCVA) of 20/20 at 3 m. Recurrence of pearls, uveitis and cystoid macular edema were the most common causes of reduced vision. Peeling and aspiration of pearls seem to be a viable alternative to Neodymium yttrium garner aluminium (Nd: YAG) laser capsulotomy for membranous PCO.


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Jun24
Bhargava R, Kumar P, Sharma SK, Kaur A. A randomized controlled trial of peeling and aspiration of Elschnig pearls and neodymium: yttrium-aluminium-garnet laser capsulotomy. Int J Ophthalmol. 2015 Jun 18;8(3):590-6. doi: 10.3980/j.issn.2222-3959.2015.03.2
Abstract
AIM:
To compare surgical peeling and aspiration and neodymium yttrium garnet laser capsulotomy for pearl form of posterior capsule opacification (PCO).
METHODS:
A prospective, randomized, double blind, study was done at Rotary Eye Hospital, Maranda, Palampur, India, Santosh Medical College Hospital, Ghaziabad, India and Laser Eye Clinic, Noida India. Consecutive patients with pearl form of PCO following surgery, phacoemulsification, manual small incision cataract surgery and conventional extracapsular cataract extraction (ECCE) for age related cataract, were randomized to have peeling and aspiration or neodymium yttrium garnet laser capsulotomy. Corrected distance visual acuity (CDVA), intra-operative and post-operative complications were compared.
RESULTS:
A total of 634 patients participated in the study, and 314 (49.5%) patients were randomized to surgical peeling and aspiration group and 320 (50.5%) to the Nd:YAG laser group. The mean pre-procedural logMAR CDVA in peeling and neodymium: yttrium-aluminium-garnet (Nd:YAG) laser group was 0.80±0.25 and 0.86±0.22, respectively. The mean final CDVA in peeling group (0.22±0.23) was comparable to Nd:YAG group (0.24±0.28; t test, P=0.240). There was a significant improvement in vision after both the procedures (P<0.001). A slightly higher percentage of patients in Nd:YAG laser group (283/88.3%) than in peeling group (262/83.4%) had a CDVA of 0.5 (20/63) or better at 9mo (P<0.001). On the contrary, patients having CDVA worse than 1.00 (20/200) was also significantly higher in Nd:YAG laser group as compared to peeling group (25/7.7% vs 15/4.7%, respectively). On application of ANCOVA, there was less than 0.001% risk that PCO thickness and total laser energy had no effect on rate of complications in Nd:YAG laser group and less than 0.001 % risk that PCO thickness had no effect on complications in peeling group respectively. Sum of square analysis suggests that in the Nd:YAG laser group, thick PCO had a stronger impact on complications (Fischer test probability, Pr<0.0001) than thin PCO and total laser energy (Fischer test probability, Pr<0.002), respectively; similarly, in peeling group, thick PCO and preoperative vision had a stronger effect on complications than thin PCO, respectively (Fischer test probability, Pr<0.001).The rate of complications like uveitis (P=0.527) and cystoid macular edema (P=0.068), did not differ significantly between both the groups. However, intraocular pressure spikes (P=0.046) and retinal detachment (P<0.001) were significantly higher in Nd:YAG laser group as compared to peeling group. Retinal detachment was more common in patients having degenerative myopia (7/87.5%, P<0.001). Recurrence of pearls was the most common cause of reduction of vision in the peeling group (24/7.6%, P<0.001).
CONCLUSION:
There is no alternative to Nd:YAG laser capsulotomy for fibrous subtype of PCO. For pearl form of PCO, both techniques are comparable with regard to visual outcomes. Nd:YAG laser capsulotomy has a higher incidence of IOP spikes and retinal detachment whereas recurrence of pearls may occur after successful peeling and aspiration. When posterior capsulotomy is needed in patients with retinal degenerations, retinopathies and pre-existing retinal breaks, the clinician should be cautious about increased risks of possible complications of Nd:YAG laser capsulotomy.
KEYWORDS:
Elschnig pearls; capsulotomy; neodymium: yttrium-aluminium-garnet; posterior capsule


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Jun24
Kumar P, Bhargava R, Kumar M, Ranjan S, Kumar M, Verma P. The correlation of routine tear function tests and conjunctival impression cytology in dry eye syndrome. Korean J Ophthalmol. 2014 Apr;28(2):122-9. doi: 10.3341/kjo.2014.28.2.122. Epub 2014 Mar 14.
Abstract
PURPOSE:
To establish the strength of the association between routine tear function tests and conjunctival impression cytology (CIC) and to determine whether they simulate the morphological and cytological changes that occur on the ocular surface in dry eye. What are the sensitivity, specificity and positive predictive values of these tests when CIC is considered the gold standard?
METHODS:
The tear film profile included tear film break up time (TBUT), Schirmer's-1, Rose Bengal scores (RBS), and impression cytology. CIC samples were obtained from the inferior bulbar conjunctiva and stained with periodic acid-Schiff and counter stained with hematoxylin and eosin.
RESULTS:
The mean Schirmer's value was 11.66 ± 5.90 in patients and 17.17 ± 2.97 in controls (p < 0.001). The mean TBUT in participants was 8.88 ± 3.54 and 13.53 ± 2.12 in controls (p < 0.001). Patients had a mean goblet cell density (GCD) of 490 ± 213, while the value for controls was 1,462 ± 661 (p < 0.001). Abnormal CIC was observed in 46.7% cases of dry eye and in 32.8% of controls. The correlation coefficient (L) for Schirmer's was 0.2 and 0.24 for participants and controls, respectively, while TBUT values were 0.26 and 0.38, RBS were 0.5 and 0.5, and GCD was 0.8 and 0.6 in cases and controls, respectively.
CONCLUSIONS:
GCD, RBS, and TBUT were better predictors of morphological and cytological changes in the conjunctiva than Schirmer's in dry eye syndrome. The sensitivity of tear function tests in diagnosing dry eye was TBUT > Schirmer's > RBS, and the specificity was Schirmer's > TBUT > RBS in decreasing order when CIC was considered the gold standard.
KEYWORDS:
Conjunctiva; Goblet cells; Tears


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Jun24
Bhargava R, Kumar P, Kaur A, Kumar M, Mishra A. The diagnostic value and accuracy of conjunctival impression cytology, dry eye symptomatology, and routine tear function tests in computer users. J Lab Physicians. 2014 Jul;6(2):102-8. doi: 10.4103/0974-2727
Abstract
AIMS AND OBJECTIVES:
To compare the diagnostic value and accuracy of dry eye scoring system (DESS), conjunctival impression cytology (CIC), tear film breakup time (TBUT), and Schirmer's test in computer users.
METHODS:
A case-control study was done at two referral eye centers. Eyes of 344 computer users were compared to 371 eyes of age and sex matched controls. Dry eye questionnaire (DESS) was administered to both groups and they further underwent measurement of TBUT, Schirmer's, and CIC. Correlation analysis was performed between DESS, CIC, TBUT, and Schirmer's test scores. A Pearson's coefficient of the linear expression (R (2)) of 0.5 or more was statistically significant.
RESULTS:
The mean age in cases (26.05 ± 4.06 years) was comparable to controls (25.67 ± 3.65 years) (P = 0.465). The mean symptom score in computer users was significantly higher as compared to controls (P < 0.001). Mean TBUT, Schirmer's test values, and goblet cell density were significantly reduced in computer users (P < 0.001). TBUT, Schirmer's, and CIC were abnormal in 48.5%, 29.1%, and 38.4% symptomatic computer users respectively as compared to 8%, 6.7%, and 7.3% symptomatic controls respectively. On correlation analysis, there was a significant (inverse) association of dry eye symptoms (DESS) with TBUT and CIC scores (R (2) > 0.5), in contrast to Schirmer's scores (R(2) < 0.5). Duration of computer usage had a significant effect on dry eye symptoms severity, TBUT, and CIC scores as compared to Schirmer's test.
CONCLUSION:
DESS should be used in combination with TBUT and CIC for dry eye evaluation in computer users.
KEYWORDS:
Computer vision syndrome; conjunctival impression cytology; dry eye scoring system; tear function tests


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Jun24
Bhargava R, Kumar P, Kumar M, Mehra N, Mishra A. A randomized controlled trial of omega-3 fatty acids in dry eye syndrome. Int J Ophthalmol. 2013 Dec 18;6(6):811-6. doi: 10.3980/j.issn.2222-3959.2013.06.13. eCollection 2013. PubMed PMID: 24392330; PubMed
Abstract
AIM:
To evaluate the role of dietary supplementation of omega-3 fatty acids in dry eye syndrome.
METHODS:
A prospective, interventional, placebo controlled, double blind randomized trial was done at two referral eye centers. Two hundred and sixty-four eyes of patients with dry eye were randomized to receive one capsule (500mg) two times a day containing 325mg EPA and 175mg DHA for 3 months (omega-3 group). The omega-3 group was compared to a group of patients (n=254) who received a placebo (placebo group). There were 4 patient visits (at baseline, 1 month, 2 months and 3 months). On each visit, recording of corrected distance visual acuity (CDVA), slit lamp examination and questionnaire based symptom evaluation and scoring was done. A symptomatic score of 0-6 was mild, 6.1-12 moderate and 12.1-18 severe dry eye. Response to intervention was monitored by routine tear function tests like Schirmer I test, tear film break-up time (TBUT), Rose Bengal staining and most notably, conjunctival impression cytology.
RESULTS:
Sixty-five percent of patients in the omega-3 group and 33% of patients in placebo group had significant improvement in symptoms at 3 months (P=0.005). There was a significant change in both Schirmer's test value and TBUT values in the omega-3 group (P<0.001), both comparisons. However, there was a larger drift in TBUT values in omega-3 than the placebo group, in comparison to Schirmer's test values. The mean TBUT score was 2.54±2.34 in the omega-3 group and 0.13±0.16 in placebo group, respectively. The mean reduction in symptom score in omega-3 group was 2.02±0.96 as compared to 0.48±0.22 in placebo group (P<0.001). Despite a slight increase mean score, the Schirmer scores did not correlate well with symptomatic improvement.
CONCLUSION:
Omega-3 fatty acids have a definite role for dry eye syndrome. The benefit seems to be more marked in conditions such as blepharitis and meibomian gland disease. The role of omega fatty acids in tear production and secretion needs further evaluation.
KEYWORDS:
conjunctival impression cytology; dry eye syndrome; meibomian gland disease; omega-3 fatty acids


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Jun24
Bhargava R, Kumar P. Oral omega-3 fatty acid treatment for dry eye in contact lens wearers. Cornea. 2015 Apr;34(4):413-20. doi: 10.1097/ICO.0000000000000386. PubMed PMID: 25719253.
Abstract
PURPOSE:
The aim of this study was to evaluate the effect of dietary omega-3 fatty acid (O3FA) supplementation on dry eye symptoms, tear film tests, and conjunctival impression cytology in patients with contact lens wear-associated dry eye.
METHODS:
In this randomized, double-blind, multicentric trial, contact lens wearers (n = 496) were randomized to receive either O3FAs or placebo capsules (corn oil) twice daily for 6 months. Subjects underwent examinations at baseline, 3 months, and 6 months. At each visit, a questionnaire of dry eye symptoms and lens wear comfort was administered. Subjects further underwent measurement of tear film break-up time (TBUT) and a Schirmer test. Conjunctival impression cytology was performed by the transfer method. Improvement in symptoms and lens wear comfort were primary outcome measures. Changes from baseline in TBUT, Schirmer, and Nelson grade at 6 months were secondary outcome measures.
RESULTS:
The mean improvement in symptom score in the O3FA group was 4.7 ± 2 (2.0) as compared with 0.5 ± 2 (0.9) in the placebo group (P < 0.0001). Lens wear comfort levels improved significantly (P < 0.0001) from baseline. There was a significant increase in TBUT [3.3 ± 2 (1.5)] and Nelson grade [0.7 ± 2 (0.6)] in the O3FA group (P < 0.0001) as compared with 0.3 ± 2 (0.6) and 0.1 ± 2 (0.4) in the placebo group (P = 0.164 and 0.094, respectively). However, the magnitude of increase in Schirmer score [2.0 ± 2 (1.5)] was relatively small (P = 0.08).
CONCLUSIONS:
The results of this study point toward benefits of orally administered O3FAs in alleviating dry eye symptoms, improving lens wear comfort, and cytological changes in contact lens wearers.


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