AIDS / HIV & HEPATITIS C INFECTION: RECENT TREATMENT MODULE OF TREATING HIV AND HEPATITIS TOGETHER WITH SOFOSBUVIR

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Hepatitic C is a silent infection like HIv and is common with many patients of hHiv particualrly those are IV DRUG USER OR BLOOD CONTAMINATED.WITH HEPATITIS C HIV MUST BE TREATED FIRST AS START ANTI HIV TREATMENT OR ARV MEDICINES FIRST KEEP VIRAL LOAD OF HIV LOW AND CD4 COUNT MORE FOR BETTER RESULTFOR HCV CURE.
Hepatitis c produce cirrhosis of liver and liver cancer if not treated,we decide to treat it when we see that Liver function of patient deteriorates,Features of cirrhosis like Pedal Oedema,Black spots,Dilated abdominal Veins,Piles or oesophageal varices with Ascites or fluid in abdome with splenomegaly starts and cirrhosis confirmed by either Biopsy or Fibroscan or Usg or we see features of cancer then we resect this liver and transplant new one and with it we treat hepatitis c too.
so,if liver enzymes alters or fetures of cirrhosis starts of if HCV viral load IU/ML OR COPIES/ML(1IU/ML=7COPIES/ML) seen in good concentration and patient opt for therapy as if treatment taken completed than unlike HIV,HCV is curable after 12-24 wks now with sobosfuvir and previously 48 wks without sofosbuvir SVR (SUSTAINED VIRAL RESPONSE) OR VIRAL LOAD ZERO OF HCV IS POSSIBLE
we see that what type of HCV it is as Genotype 1 or 1A or 1B or type 2,Type 3 or type 4 .Genotype HCV 1A and type 4 are hard to treat they need peglyated Interferon with Ribvarin for 24-48 wks with Bocprevir and telaprevir either if alone or with HIV but with Sofosbuvir now it is found that interferon-free regimen of sofosbuvir plus ribavirin for 24 weeks led to sustained response in three-quarters of previously untreated people with genotype 1 hepatitis C and HIV co-infection in the PHOTON-1 study,and 12 wks therapy for type 2 but for type 3 also a course of 24 wks needed like type 1A not shorter 12 wks as for type 2 as we think type 2 and type 3 are easy responders.according to a report at the 21st Conference on Retroviruses and Opportunistic Infections (CROI 2014) this week in Boston.

People with HIV/HCV co-infection experience more rapid liver disease progression and do not respond as well to interferon-based therapy as people with hepatitis C alone. Direct-acting antivirals like sofosfuvir or SOVALIDI or PREVIOUS KNOWN GS-7977 that target different steps of the HCV lifecycle offer the prospect of shorter treatment, fewer side-effects and higher cure rates for both HCV mono-infected and HIV/HCV co-infected patients.In less advanced case or type 2 or type 3 simprenavir can also be tried.Previous to this costly Sofosbuvir (ruprees 50000 dollars for one month )but pegylated Interferon is very toxic and cannot be easily tolerated by every pateient previously we were using INTERFERON ALPHA 2a OR ALPHA 2b which dose was twice a week but now pegylated once a week injection,Ribarin in dose 0f 1000-1200 mg as per body weight and Sofosbuvir 400 mg once a day only.

HIV / AIDS: CONTRACEPTIVE & HIV PREVENTING VAGINAL RING DISCOVERED,BEING USED TO PREVENT PREGNANCY & HIV

PROF.DRRAM ,HIV/AIDS,SEX DIS.,SEX WEAK.& ABORTION SPECIALIST
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AN INTRAVAINAL RING HAVING LOADED MEDICINES TENOFOVIR (AN HIV ARV NRIT MEDICINE) AND LEVONORGESTREL (A CONTRACEPTIVE) has been developed by Northwestern University biomedical engineer Patrick Kiser .This is first-of-its-kind intravaginal ring 'reliably delivers' an antiretroviral drug and a contraceptive for months.
The device is designed to protect against HIV and herpes as well as unwanted pregnancy. It will be the first device with the potential to offer this protection to be tested in women.

According to the World Health Organization, 35 million people around the world live with HIV, and 222 million women would like to delay or stop childbearing but are not using any method of contraception.“I suspect women will use the ring primarily for contraception, but they also will benefit from protection against sexually transmitted diseases,” said Kiser, an expert in intravaginal drug delivery. “And for women in the developing world in particular, unwanted pregnancy can have significant health, economic and cultural consequences. We want to motivate women to use this ring.”

The ring, 5.5 centimetres in diameter, is simple yet complex. Kiser and his colleagues worked painstakingly for five years, engineering the three materials that make up the ring and optimizing the device to reliably deliver fixed and efficacious doses of two medicines over a long period of time.the ring is easily inserted in the vagina and stays in place for three months. And because the tenofovir is delivered at the site of transmission, the ring – known as the tenofovir levonorgestrel IVR – utilizes a smaller dose than pills. The levonorgestrel released by the ring is the same drug as that used in certain contraceptive pills and in an intrauterine device.

Tenofovir is taken orally by 3.5 million HIV-infected people worldwide, and it also has been studied as a gel. The drug inhibits HIV and HSV-2 (herpes simplex virus-2) replication in susceptible cells.

Previous studies have demonstrated that antiretroviral drugs can prevent HIV infection, but existing methods for delivering the drug fall short. Pills must be taken daily and require high doses; some women may prefer a longer-lasting method, such as the ring, versus methods used at the time of sex, such as a gel.
The antiretroviral drug section of the ring is made of one kind of polyurethane, and the contraceptive section of the ring is made of another polyurethane. Each material needed to be engineered with the correct diffusion rates, so the encapsulated drug is released into the body at the desired rate, providing the correct dose.

A third polyurethane material between the two sections keeps the drugs separate. All the parts are welded together to complete the ring.

HIV AIDS: LONG ACTIVE ONCE INA QUARTER MEDICINE IS ON WAY :

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A long-acting, injectable HIV drug could potentially protect people from infection with the AIDS virus for up to three months, new animal studies suggest.The experimental drug, called GSK744, protected macaque monkeys from repeated attempts to infect the animals with a hybrid simian/human AIDS virus called SHIV, scientists said.

GSK744 is a reformulated, long-acting version of an HIV drug known as dolutegravir (Tivicay), which has been approved by the U.S. Food and Drug Administration for treatment in people who have already been infected with HIV and is now used in many combination as primary or secondry drug in USA AND UK but not IN OUR ART CENTRES .these are less toxic and having less side effects and reisitant to virus is almost unknown.

While GSK744 hasn't been tested on humans, doctors hope that it will lead to a medication that could effectively protect people against HIV infection, mostly because it would only need to be administered on a quarterly basis. However, findings from animal studies often don't hold up in human trials.

Such a long-lasting drug would help overcome one of the major problems with current medications that attempt to protect against HIV infection -- the ability of people to take their medication on a daily basis.

"Some of the really good pre-exposure prophylaxis treatments have not been effective, mainly because people don't take the drug," said Dr. Anthony Fauci, director of the U.S. National Institute of Allergy and Infectious Diseases. "The major stumbling block the field has experienced has been the lack of adherence. It's not because the drugs don't work. It's because people don't take them as directed."

Researchers expect to launch human trials for GSK744 within a matter of months, said study author Chasity Andrews, a scientist with the Aaron Diamond AIDS Research Center at Rockefeller University in New York City.

GSK744 is in a class of antiretroviral drugs called integrase inhibitors. These medications block HIV from inserting its genetic material into the body's immune cells.

GSK744 is different in that it crystallizes in the bloodstream, allowing a slow, steady release of the medicine over time, the Rockefeller researchers explained.

Their findings are published online March 6 in the journal Science. The Rockefeller study, and similar results from a study conducted by researchers at the U.S. Centers for Disease Control and Prevention, were presented Tuesday at the annual Conference on Retroviruses and Opportunistic Infections in Boston, according to published reports.

The medication levels that protected the monkeys translate to doses that could sustain human protection for 12 weeks to 16 weeks, Andrews said.

Effective protection against HIV is necessary to fight the spread of AIDS. There were 2.3 million new HIV infections globally in 2012, the researchers noted in background material, with more than 35.3 million people already infected. — with AidsControl Empl India and 19 others.

मूळव्याध
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टॉयलेट मधील अवान्छीत रक्तदान थांबवा !!!!!!
मूळव्याध म्हणजे शौचमार्गाकडील रक्तवाहिन्या फ़ुगून बाहेर येणॆ व रक्तस्त्राव होणॆ
कारणॆ-मलावरोध,बध्द्कोष्ठता,सन्डासला जोर करणॆ,कुन्थणॆ,तन्तुमय जेवण न घेणॆ,व्यायामाचा अभाव, पाणी कमी पिणॆ, धुम्रपान,जाडीवाढणे ,मद्यपान,मांसाहार,जड वजन उचलणॆ इत्यादी.तसेच गर्भवती स्त्रिया व प्रसुती नंतर हा त्रास वाढतो.
लक्षणॆ- कोम्ब बाहेर येणॆ,शौचास कडक होणॆ,शौचासदूखणॆ,पोटदूखणॆ,रक्तस्त्रावहोणॆ,खाजणॆ,जडपणा वाटणे,एनिमिया,अशक्तपणा येणे
ह्यामधील कोणत्याही लक्षणास दुर्लक्षू नये व माझा सल्ला घ्यावा.कारण मूळव्याध व कर्करोग एकाचवेळी असु शकतात.
निदान-सर्जनकडील योग्य तपासणी,प्रोक्टॊस्कोपी व सोनोग्राफी करणॆ,तपासताना भूलेची गरज नसते.
उपाय- शस्त्रक्रिया हाच एकमेव उपाय "एक टाका पुढचे नऊ टाकॆ वाचवतो".
वेळेत शस्त्रक्रिया हेच एकमेव उत्तर आहे.
होमिओपॅथि अथवा आयुर्वेदाने पुर्ण बरा न होणारा आजार आहे.
आहारातबदल,सॅलड,कोन्डा,तन्तुमयजेवणघेणॆ,पाणी
भरपूर पिणॆ,मेडीकल/औषधे,क्रिम्स,लॅक्जेटीव्ज घेणॆ
बॅन्डीन्ग,कोयाग्युलेशन,हेहि ओप्शन आहेत.
मूळव्याधिचे कोम्ब हा फ़िशरचा प्रकार असुन त्याचि शस्त्रक्रिया करावि कारण ते दुखतात,पु होतो ,फ़िस्तुला होतो.कोम्ब व पाइल्स बरे करनारि औषधे अस्तित्वत नाहीत.
पारम्पारीक मूळव्याध शस्त्रक्रिया हि गोल्ड स्टॅन्डर्ड शस्त्रक्रिया मानली जाते,कमी खर्चात होते, व आत्यधुनिक औषधे असल्यामुळॆ वेदनारहित होते,टॊईलेटवरिल ताबा कधीच जात नाही,पण बरे हॊण्य़ास २ दिवस लागतात. आता हार्मोनिक /कॉटरी वापरून लवकर बरी होते.हा आजार शस्त्रक्रिया करुन घेतल्यास पूर्ण बरा होतो कारण औषधे फ़क्त तात्पुरता आराम देतात.
स्टॆपलर वापरुन केलेली- २१व्या शतकातील नवी शस्त्रक्रिया,२ दिवसात घरी जाता येते, कमी दुखते,पुन्हा होत नाही,रक्तस्त्राव होत नाही, पण महाग आहे.
मेडिकल/औषधे घेउन आजार वाढवण्य़ापेक्षा सर्जन कडून तपासणॆ व पूर्ण बरे होणॆ महत्वाचे.
स्वउपचार व मेडीकल मधून स्वतःची स्वतः औषधे घेणे टाळा.
स्त्रीपेशंटची स्त्रीसर्जन कडून तपासणी केली जाते त्यामुळे त्यांना न संकोचता दाखवता येते.
तसेच स्त्री व पुरुषांच्या कमी खर्चात शस्त्रक्रिया होतात त्यामुळे पेशंटचा फायदा होतो.
मूळव्याध न होण्यासाठी काय कराल?
वजन कमी करणे,पाणी भरपूर पिणॆ, तन्तुमय जेवण घेणॆ,मलावरोध व बध्द्कोष्ठता टाळणॆ,ब्येथे काम तालने
व्यायाम करणे, न कुन्थणॆ, सर्जनचा सल्ला घेणे सर्वात महत्वाचे.
मोफत तपासणी शिबिर- ६ ते ९ औगस्त २०१३ वेळ- ७ ते ८.३० with appointment

HOW TO GET BEAUTIFUL AND GLOWING SKIN
How Water Benefits Your Skin

Few things are as good as water for keeping your skin in shape.

Water keeps skin hydrated, reducing the look of fine lines and wrinkles. It helps cells take up nutrients and purge toxins. And water improves circulation and blood flow, keeping your skin glowing.

Selenium for Your Skin

Selenium is a trace mineral that may help protect skin cells from free radical damage. It may also play a role in skin cancer prevention.

Excellent sources of selenium include Brazil nuts, button mushrooms and whole-wheat pasta

CoQ10: Coenzyme Q10

CoQ10 is a powerful antioxidant made naturally in your body. However, its production decreases with aging. CoQ10 protects skin and other body cells from the damage caused by free radicals. It's also involved in energy production and basic functioning of cells. Low levels of this antioxidant are found in many age-related illnesses. When used topically, it is reported to improve the appearance of wrinkles and the signs of aging.
Rich sources of CoQ10 include fish (such as salmon and tuna), poultry, organ meats (such as liver), and whole grains.

Antioxidants for Healthy Cells

Antioxidants prevent or slow the damage done to cells by free radicals. This damage contributes to signs of aging, such as wrinkles and dry skin.
Antioxidants can be found in all kinds of foods, especially colorful fruits and vegetables such as berries, tomatoes, apricots, beets, squash, spinach, sweet potato, tangerines, peppers, and beans

Vitamin A for Skin Repair

Want to steer clear of dry, flaky skin? Grab an orange, a carrot,and papaya. These fruits and vegetables are loaded with vitamin A. Applying vitamin A to the skin appears to improve signs of aging, such as wrinkles. Topical and oral forms of vitamin A are common prescription treatments for acne and other skin conditions, including wrinkles. Other sources of vitamin A include leafy greens, eggs, and low-fat dairy

Vitamin C: Power Over the sun

Vitamin C helps protect skin from the sun. It also helps undo damage done by free radicals, which destroy skin-firming fibers such as collagen and elastin.

Excellent sources of vitamin C include red bell peppers,guava, indian gooseberry(amla) citrus fruits, papaya, kiwi, broccoli, greens, and brussels sprouts.

Vitamin E is another antioxidant that may help shield your skin from damage done by the sun. Vitamin E is also an anti-inflammatory and immunity enhancer.

Vitamin E is found in vegetable oils, nuts, seeds, olives, spinach, asparagus, olives, and leafy greens in small amounts.

Essential Fatty Acids for Your Skin

Essential fatty acids such as omega-3s and omega-6s help produce your skin's natural oil barrier, keeping dry skin and blemishes at bay. EFAs are necessary fats that help leave skin smoother and younger-looking.

Good sources of essential fatty acids include olive and canola oils, flax, walnuts, and coldwater fish such as salmon, sardines, and mackerel

Healthy Oils for Healthy Skin

Some oils pack more than essential fatty acids. Good-quality oils like extra virgin olive oil and cold- or expeller-pressed oil are more simply processed than many commercial oils, and so they may help retain more skin-boosting nutrients.
These oils may also help lubricate skin and keep it looking and feeling healthy

Green Tea: Antioxidant Powerhouse

Green tea may be the closest thing to a magic elixir that nature can offer for your skin. Green tea helps to stop inflammation, slow DNA damage, and can help prevent the sun from burning your skin.