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Mar22
Cardiology-Sudden Cardiac Death
Sudden Cardiac Death
According to the American Heart Association, Sudden Cardiac Death (SCD) affects approximately 450,000 people each year in the United States and an estimated 95% die before reaching the hospital. SCD kills more Americans than lung cancer, breast cancer and AIDS combined. SCD or Cardiac Arrest is reversible in most victims if it’s treated within first 3 minutes by the delivery of an electrical shock.
With the development of hospital coronary care units in the 1960s, it was found that electrical devices that shocked the heart could turn an abnormally rapid rhythm into a normal one.
Later, it also became clear that cardiac arrest could be reversed outside the hospital if specially trained emergency rescue teams reached the person quickly. The chances of survival are reduced by 7-10% with every passing minute. However, even after survival, the prognosis continued to be dismal. The first-year recurrence rate in survivors of SCD was 20-40%.
SCD victims range from young children to the elderly.
SCD is caused by the rapid and/or chaotic activity of the heart known as ventricular tachycardia (VT) or ventricular fibrillation (VF). This is the problem of electrical conduction system of heart and should not be confused with a heart attack (myocardial infarction), which is caused by a blocked blood vessel leading to loss of blood supply to a portion of the heart muscle. However, some people may experience SCD during a heart attack. However it has been observed that people are scared of heart attack but do not understand the concept of SCD.
Both ventricular tachycardia (VT) and ventricular fibrillation (VF) are life-threatening heart rhythms. In hospital these arrhythmias can be treated with external defibrillators by the paramedics or medical personnel. However, for long-term out of hospital treatment option an electronic device (ICD) is implanted in the patient’s body to treat these arrhythmia.
An Implantable Cardioverter Defibrillator (ICD) monitors the heart’s electrical conduction system and delivers electrical energy (shock) to the heart to convert VT/VF to a normal rhythm.
In the mid-1980s, the ICD was designed and was called “an emergency room in the chest”. Today, ICD’s do much more and have been proven to be 99% effective in treating these ventricular arrhythmias and preventing SCD. As of today, ICD is about the size of a small stopwatch and is implanted in the upper chest, below the clavicle bone. It continuously monitors the electrical conduction system of the heart, watching for dangerous patterns and delivering electrical impulses when needed that may range from a tiny pulse like a cardiac pacemaker or a life-saving shock that can return the heart to normal rhythm.
Risk of SCD is high in patients with:
*At least one experience of VT/VF
(malignant rhythm arising from lower chamber of heart)
*Previous cardiac arrest or abnormal heart rhythm that caused patient to pass out
*A fast heart rhythm that keeps returning and could cause death
*A fast heart rhythm that cannot be controlled with drugs
*Severe side effects from drug therapy used to control these fast rhythms
*Previous heart attack and a low ejection fraction (poor heart function)


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Mar20
Cosmetic Surgery is Necessity not Luxury
Cosmetic Surgery is Necessity not Luxury
Written By:
Dr.B.P.Singh M.D.,FACCS,FIAMS,FIACS
Board Certified Cosmetic Surgeon
CERTIFIED BY INTERNATIONAL BOARD OF COSMETIC SURGERY
Fellow of International Academy of Cosmetic Surgery
Fellow of Australasian College of Cosmetic Surgery
Fellow of Academy of Medical Specialties
Member International Board of Cosmetic Surgery
Member International Academy of Cosmetic Surgery
Chairman : IMA Academy of Medical Specialties Punjab
National Academic and Research Committee Member IMAAMS New Delhi
C E N T R E F O R L A S E R C O S M E T I C S U R G E R Y
B H U P I N D E R N U R S I N G H O M E
261, Mota Singh Nagar, Jalandhar 144001 Punjab INDIA
Phone : 91-181-2224228, 2223376, , Mobile : 91- 99142 18261
Websites : www.cosmeticsurgerybp.net ; www.cosmeticsurgeryinindia.com ; www.ienhanceu.com

Cosmetic Surgery is a new superspecialty of body shaping, sculpturing individual body parts to enhance beauty, figure and looks. But, the need and concept to beautify oneself is time immemorial. Uses of flowers, leaves, plant twigs were used in early stages of human civilization. Use of stones and animal bones are well known. Ivory products are known to enjoy high position and preferential status in society from olden times. Even today some cultures still use ivory and stone ornaments. Uses of pearls are well known. Now-a-days jewelry made of silver, Gold, Diamond, Platinum and precious stones are preferred choices of elite classes.
Use of various cosmetics to enhance beauty is in practice for almost all body parts, namely, lips, eyebrows, eyelashes, forehead, full face, hairs and nails of hand and feet. Use of pricks and studs in ears, nose, umbilicus and many many more parts, may be difficult to imagine their utility by some persons, but, are the need of many.
Need to look better than others and to stay young with youthful appearance have kept the mankind in race to search better and newer options. One such practice is COSMETIC SURGERY. Number of people accepting cosmetic surgery as the final answer to their requirements is increasing every day. The fact that total cosmetic surgery procedures done world wide every year outnumbers the sum total of all other surgeries put together is enough recognition.
Let us try to understand why one will need to go for cosmetic surgery. Clothing, ornaments and use of cosmetics can give feeling of betterment to those bodies that are basically in shape and figure. Faces with wrinkled skin, crooked nose, bulky and fatty belly cannot and will not look better with the use of non surgical means listed above. Media has played a vital role in spreading message of the significance, value and importance of human appearance. Wisdom prevailing in individuals takes them to the doors of cosmetic Surgeon for the definitive corrections.
Other class of persons who are not happy with the given shape, size or profile of one or more body parts suffer from ‘complex’ in their minds. These fail to perform efficiently. Cosmetic surgery comes to their rescue to transform their lives.
In every one’s life, time comes when they look for an ideal life partner. No one is ready to compromise on any thing less than the best. Education and status are important and are adequately matched. Verdict on appearance and presentable personality is final. When a boy is rejected on the ground that his nose was not of right shape or girl refused for thick lips or flat chest, imagine the magnitude of suffering which gloom in their head. After two or three such failures, hidden dejection comes to surface; it shows its presence on every one in family, thus attaining the picture of a social problem. Importance of Cosmetic Surgery as necessity is not better understood by any one else than such sufferers sailing in the same boat.
Similar situation arises when all suitable educated well trained and competent people queue-up for a job. Selection of most beautiful candidate leaves behind rest with small faces, depressed and dejected lot. Those who have faced such agony can only appreciate the plight of such defeated lot. Their feeling is that of ‘defeated from one self own’. Since they do not want to lag behind any one, their answer is in getting themselves improved, or enhanced or beautify themselves with the help of a competent, qualified, experienced, certified and recognized cosmetic surgeon. He restores their confidence and brings them to fore, second to none.
Few happily married people also come for cosmetic surgery. These are who do not want to see any short coming in their partner. Their submission is, if we can correct the needful shape and size of the breast or any other part, why not to do it. Wisdom which prevails in their mind is not to compromise and their counterpart has to look in perfect shape.
Remember, a lady who kept her shape and figure with utmost care, regular exercising, very judicious control on diet and intakes gets her family with cute little babies, but, lost her figure and shape while she is not even 30. Whole of the life is in front and now no charm in wearing choicey outfits, accepting the glare of watching people as if she is middle aged woman. She has right to live her life the way she wants. She wants to be in shape. She joins yoga classes and many more promising institutions wasting lots of her precious time and hard earned money – with no result outcome. Their looseness on tummy is still there, flanks are full and shaped as folds, breast sagging, face pigmentations, glow and charm on face is lost. Much needed enjoyment between the partners is missing. Noticeable change in attitude of husband is disturbing. To go for cosmetic surgery becomes an imperative need.
It is imperative that your dress code and activities should be in accordance with the prevailing rules of society. You should be ‘In Fashion’. To be a part of beach culture, pubs and parties, you need to dress up with ‘in fashion’ outfits; really showing most of the curves and delicately shaped attractive body. You wish to be ‘In focus’ and admired by others. An experienced cosmetic surgeon will quickly get your point, how so ever small it may be. Sculpturing your body to your need is an art. Perfect execution of which classifies cosmetic surgeons as ‘Good’ or ‘Average’. Uncompromisingly, desire to stay on top, drives you to the cosmetic surgeon, who will show his ability and technical skills of art and science sculpturing and crafting your delicate body.
Quite good number of middle aged patients comes for cosmetic surgery because the teenagers want their parents to look young and smart. Particularly, when younger one wants their friends or would be partners meet their mom and dad. They do not want to loose any point. Necessity role of cosmetic surgery comes to play.
Divorced persons before starting hunt for new partners addresses themselves to know what has gone wrong with their body now. With the help of a cosmetic surgeon they get corrections what they need. Most common are liposuctions, tummy tuck, breast uplifting, sizing and shaping, facial cosmetic surgery, peels and vaginoplasty-size and shape corrections.
Database of the patients coming for cosmetic surgery are stating that male to female ratio is almost equal. Almost all age groups are represented as patients. Need for cosmetic surgery is almost as equal to lower and middle income group as to upper and affluent classes.
Accidental injuries are part of life. When it comes to injury on face or other visible parts, every one is upset. If patient gets services of a cosmetic surgeon; who helps in avoiding bad prominent scars to minimally visible or almost invisible scars; feels satisfied and happy too.
Struggle for existence and survival of fittest are laws of the nature. Meaning and relevance of these are now better understood with increasing competition. Role of cosmetic surgery is in keeping humans fit in shape and figure, young and youthful - to stay in front.
Gone are the days when people use to say that cosmetic surgery is only for rich people who can afford to enjoy luxury. Scenarios presented above are the every day stories and happenings of most of us. Yet some people shy in admitting its need, while, more and more people are coming forward to obtain solutions of their daily problems.


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Mar19
Cosmic Healing and Beauty
It has now become a trend that we blindly take cosmetic products for every kind of skin problem we have. There are a lot of people having pimples on their faces, some have dark spots, wrinkles and a lot other such problems. The problems overshadow our beauty and apperence and hence we start spending enormous money on various kinds of cosmetics and surgeries available in the market.

We always forget that our body is not designed for such harsh treatments and hence we damage our skin in a terrible mannar. A polished advertisement with an actor or actress makes us believe on the product and we without even cosidering the ingredents involved, start using those products.

But the question that arises is from where exactly these problems arises? To know the root cause of the problem, we need to look inside ourself as what we are watching on our face or body is just a mini reflection of what is happening inside the body. It all appens due to hormonal imbalance and disturbed metabolism. I know these are very impressing terms but to simply the problem, it all starts with our lifestyle. The way we sleep, the way we eat, the way we breathe are all interconnected and together form the symptoms of positive or negative lifecycle.

The damage we do to our body is due to our indisciplined lifestyle and it is what reduces our skin radiance. I understand that it is very difficult to change our lifestye but atleast in return of so much work that our body does for ourself, we need to provide it with something better than sleep.

Believe me, an hours meditation will give more energy than an 8 hour sleep. You need to meditate, if not an hour than atleast 10 mins on a daily routine and just stop taking your lunch. It does not mean you need to stay hungry. Eat a plate full of fruits and vegetables and watch the difference.

If you gift your body just two of these things, then you need not to spend a single penny on 'Loose your weight shops' or 'Skin clinics' or any beauty creams or facials or whatever.

You can save a lot of your money which you spend unnecessarily and all you need to do is a the above mentioned exercises with discipline. Start doing them once and slowly you will become habitual. Allow your body to show its magic.
ITS ALL IN YOU. . . . . .


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Mar19
Common questions on pimples by Skin specialist Dr. Rajan T.D. MD,DVD,DNB.
Q. My parents say that they never took treatment for pimples. As a specialist what is your opinion about youngsters seeking treatment for this complaint?

In the past decade several new chemicals have been introduced for treating pimples which were not available when your parents were young. Also, some of the currently available agents help to remove blackheads and thereby minimise the chances of large pimples. In this manner we can minimise marks and scars. Although acne or pimples are a problem related to age, it is better that treatment is promptly taken to prevent ugly-looking scars which are difficult to clear.

Q.Why is squeezing of pimples harmful?
Imagine squeezing a pipe - the contents will move in both the directions! There is no doubt that when the pimple is squeezed it expels some amount of pus. At the same time it causes aggravation of the inflammation in the deeper part of the skin. Also, if the nails are not kept clean it could add to the bacterial contamination of the oil glands in the skin. Therefore, it is not advisable to fiddle with the pimples.

Q. I am an 18-year old girl suffering from severe pimples. I have stopped consuming fried and oily foods for the past 6 months, yet my face is not showing any improvement. Please advise.
Although it was believed in the past that the diet is srongly related to the occurrence of acne the current finding do not give much weightage to diet alone. Pimples are caused by several factors interacting with each other. Of these, diet is only a minor factor and hence you are not advised to stop intake of oily foodstuffs completely.
It is also important to remember that boys and girls suffering from severe form of pimples need to take proper oral medicines as well as creams to get good recovery. Simply depriving oneself of the good things of life does not solve the problem!



Q. I have extremely oily skin over my face and I occasionally get pimples. Which cream or cosmetic should I use to make my skin dry?
You are fortunate not to have too many pimples despite having an oily skin. The amount of oil produced by one's skin cannot be altered by external applications. Wash your face with soap and water at least three to four times a day to remove excess oil. Consult a specialist if your pimples are persistent or if they produce lot of discomfort so that an appropriate medicine can be prescribed.

Q. My face is quite oily but I had a very clear complexion till I underwent a facial 4 months ago. Since then I keep getting large clusters of pimples which cause lot of pain. Could there be a connection between the two?
Pimples develop through two main mechanisms: excess oil (sebum) production in the skin and blockage of the pores (sebaceous ducts) which carry the oil outwards. It is possible that when you underwent facial, the preparation used was massaged deeply into the skin. This may have clogged the already narrowed pores resulting in pimples. You should avoid massaging any oily preparation into your skin or it could further aggravate the condition.


Q. I have several red eruptions and tiny blackheads on my cheeks since few months. How long does the treatment take to clear my face?
By and large an 8-week course of medications help to clear the pimples and blackheads. This does not mean that they clear permanently. After the course of treatment the pimples and blackheads reduce by about 80% and the fresh eruptions can be promptly treated with mild local agents which prevent scarring.

Scars produced in the past will take several months to clear with local gels. Even if no treatment is taken, the scars fade gradually.

Dr. Rajan T.D., MD,DVD, DNB
Specialist in Skin & Sexually Transmitted Diseases
102B Samrock Apts, Juhu Lane,
Andheri West, Mumbai, India
Tel: 0091-22-26705557 / 66982747


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Mar18
THE MAGIC OF PLASTIC and COSMETIC SURGERY !
THE MAGIC OF PLASTIC and COSMETIC SURGERY !
Written By:
Dr.B.P.Singh M.D.,FACCS,FIAMS,FIACS
Board Certified Cosmetic Surgeon
CERTIFIED BY INTERNATIONAL BOARD OF COSMETIC SURGERY
Fellow of International Academy of Cosmetic Surgery
Fellow of Australasian College of Cosmetic Surgery
Fellow of Academy of Medical Specialties
Member International Board of Cosmetic Surgery
Member International Academy of Cosmetic Surgery
Chairman : IMA Academy of Medical Specialties Punjab
National Academic and Research Committee Member IMAAMS New Delhi
C E N T R E F O R L A S E R C O S M E T I C S U R G E R Y
B H U P I N D E R N U R S I N G H O M E
261, Mota Singh Nagar, Jalandhar 144001 Punjab INDIA
Phone : 91-181-2224228, 2223376, Mobile : 91- 99142 18261,
Websites : www.cosmeticsurgerybp.net ; www.cosmeticsurgeryinindia.com ; www.ienhanceu.com


The setting is that of a hospital. As you walk in you can see the patients sitting, waiting for their turn at the reception. One is an obese, the other has a cut lip, yet another has a deformed nose. A grim and grotesque scene for a casual passerby. As you move further, you can see a doctor giving consultation to a lady who is excessively overweight. "Just three sittings" he says," and you will be fine". Another patient goes in to consult the doctor. A young man has multiple scars on his face.They have a small discussion. The doctor assures him of wiping out these scars completely. He comes out of his office. Suddenly, a man comes forward and gives him a tight hug. There were tears of happiness in his eyes. His sister's face was burnt and scarred in half. This doctor had restored her face and had given her a fresh lease of life. Tomorrow his sister was getting married. He held in his hand an invitation for the doctor. Surprises are a part and parcel of this hospital. These are some of the humanistic scenes one is bound to encounter everyday. This is a hospital for Cosmetic & Plastic Surgery.
In today's competitive and fast moving world, one's personality counts a lot in all kinds of situations. Every one has to keep up appearances on many occasions with a variety of important people in everyday life. The extraordinarily huge increase of the private and corporate sector has also brought in the trend of better dressing and a well-groomed look. People all over the world have become very conscious about their looks, their weight, their walk and their overall physical appearance. It is not easy for an obese person to look away from the staring eyes of the people. Nor is it easy for a person to hide a scar of an accident. It is life sentence for a girl who cannot marry because her face bears White marks. These small handicaps can tarnish one's career while on a high profile job. Now, there is a way out for every person who wants to live his/her life on his/her own terms. The relief comes in the form of Cosmetic & Plastic Surgery, which has restored millions of lives all over the world. Along with the womenfolk, these procedures are also very popular among men all around the world.
The term Plastic Surgery actually means to mold or to give form. It is an effective tool to rectify functional and structural deformities of the human body.
Reconstructive surgical procedures are carried out with the goal of restoring form and in many cases function of body parts that are deformed due to injury, disease, or congenital defects. The primary consideration here is the fact that the procedure is carried out on abnormal parts or tissues in an attempt to restore it to a more normal appearance and to improve function. For example, removal of skin cancers, repair of cleft lips and palates, improving upon private parts etc.
On the other hand, Cosmetic procedures are operations done purely to enhance the appearance of body parts, which fall within the normal range of appearance and function. Cosmetic surgery deals with the beautification of different parts of the body. For instance, a person can have a bad looking nose, a beautiful young girl is unhappy by the size of her breast, some extra deposits of fat have taken away the attractive figure of a young mother, lines of ageing clearly seen on once face and lot more. These can be easily corrected through a small cosmetic surgery operation.

Cosmetic Surgery incorporates various procedures, which give a better look to our overall appearance. Some such procedures are Face Lift, Blepharoplasty (Eyelid Surgery), Rhinoplasty (Nose job), Breast reconstruction, augmentation and reduction, Liposuction, Lipoinjection etc.
A Facelift is a surgical procedure designed to reduce the visible signs of aging such as creases in the face, slackness in the jaw line and accumulation of fat around the neck. This procedure gives the patient a visibly younger looking face by removing the signs of aging. Most patients who consider facelifts are in there 40s and 60s but it can be successfully performed on people in there 70s as well. Similarly, there is a procedure called Blepharoplasty that is simply known as an Eyelid surgery. It is a procedure to remove fat, and sometimes excess skin and muscle, from the upper and lower eyelids. It is simply used to remedy the sagging skin and weakened muscles that occur around the eyes over the time and can make a prospective person look older and tired. After just a few weeks of this procedure the patient gets a very youthful and alert look.
One of the most popular Cosmetic surgeries all over the world is Breast Augmentation and Reduction. These are basically two procedures, which have brought welcome relief to women all over the world who want to give a shapelier look to the upper part of their bodies. Breast augmentation and reduction are procedures, which are performed to balance a difference in breast size and improve the body contour. In the same way, the Chemical Peel technique is also helping a large number of women around the world. It is a non-invasive technique that is designed to restore wrinkled, blemished, unevenly pigmented or sun -damaged facial skin. Using a chemical solution, the skin's top layers are peeled away, allowing for new cells to grow that produce a smoother, tighter, younger-looking skin surface. This procedure is also very popular among men.
A very important and successful cosmetic procedure is Liposuction. This is a cosmetic surgery operation to correct figure and shape the body permanently. All over the world people are becoming very conscious about their extra fat and weight. Today, they have realised the negative aspects of overweight and are making efforts to bring down their extra body weight. But inspite of all this there are some regions of the body, which remain fatty and don't come to an acceptable shape. Liposuction is a procedure to remove unwanted fat deposits from specific areas of the body such as the face, abdomen, buttocks, thighs and elsewhere. Fat is sucked out along with fat cells; hence, give permanent results of correcting figure.
Another significant procedure which is the very opposite of Liposuction is called Lipoinjection. This is the procedure through which fat is put into various parts of the body to give it a more rounded and firm look like cheeks, breasts, neck etc. This procedure is especially popular among persons who are very thin and want a shapelier look to them.
Another popular technique is the procedure of Hair transplant. This procedure is currently in vogue among all kinds of persons, especially middle-aged men, in a number of countries. The surgery of the nose or Rhinoplasty is another technique by which the shape of the nose is greatly improved to near perfection. Commenting on this procedure Dr. Singh says, "A Cosmetic surgeon ought to have a good aesthetic sense for a nose job. The patients can present their needs but it remains upon the surgeon to decide which shape would suit a certain face properly. The surgeon should be absolutely honest about this procedure to the patient." In the similar way, Otoplasty or ear surgery restores the size of the ears to normal and also brings prominent ears closer to the head.
Stigma of white patch needs special mention. According to doctors a stationary white patch is not a disease, it is only a cosmetic defect in skin due to non functioning of colour producing cells. But, a person having such white spots has to face rough and discriminating attitude of the society. He/she has to suffer always in spite of their all merits. Cosmetic surgery can alleviate this social problem by transplanting colour cells on the stationary white areas so that normal skin tone is regained. Not only a person, society as a whole is benefited.
There is a general misconception among people all over the world that Cosmetic surgery is a very expensive affair. They are also misguided in their notions that it can be afforded by only the rich and affluent people. Nothing can be farther from the truth. Today, doctors all over the world have realised the increased importance of a good appearance for everybody and it's important role in the daily routine. Due to extensive studies and experiments, they have developed numerous techniques, which have increased the arena of Plastic surgery and Cosmetic Surgerys techniques in a tremendous manner. There has also been a rise of the middle and upper middle class people who have become more conscious about their physical appearance for more success in life. Now, the cosmetic and plastic surgery techniques are available to all classes of people at marginal and cost effective prices all over the world and people have already started making use of it's benefits.
Along with the lower prices, these procedures have also become very safe and reliable in the past decade due to which more and more people are opting for the help of these techniques to their benefit. From India, a Cosmetic and Plastic surgeon who has gained an immense popularity among cosmetic surgeons of the world is Dr. B.P.Singh. It is a general perception among people everywhere that the countries of the West are the sole authorities and experts on the subject of Cosmetic surgery. It is also believed that surgeons in the West have done all the new innovations in this field. But this perception has been proved wrong by Dr. B.P.Singh who is running the International Center for Cosmetic & Plastic Surgery at 261,Mota Singh Nagar in Jalandhar, Punjab. He is the only Indian surgeon and the only one from South East Asia to have been invited to World Congress on Cosmetic Surgery at Sydney, Australia, in the year 2001, which was attended by surgeons from 70 countries. His patients consist of NRIs from UK,US, Canada, European and the Gulf countries. His improved techniques of Liposuction and Lipoinjection have brought a revolution among cosmetic surgery. Infact, he has won two prestigious International awards viz., 'World Leader of Cosmetic Surgery' and 'Best Scientific Presentation Award' for his outstanding contribution in the field of Cosmetic Surgery. Today, his techniques are being used by Plastic surgeons all over the world. The new Lipoinjection technique as perfected by him has been named after him as 'Singh's Lipo Injection Technique'.
In the earlier procedure of Liposuction, only 3 liters of body fat could be removed in one sitting. Moreover the time gap kept in between each sitting was of three months. This led to an anguished wait for the patients. Due to his extensive studies and research, Dr. B.P.Singh was able to lessen the time gap in between each sitting and also devised a technique by which 6 liters of fat could be taken out in one sitting itself. In case of Lipoinjection, the old procedure could inject only 2 to 5 c.c of fat at one time. Due to the small amount injected, the benefits of this process could not bring any visible change. Today, with 'Singh's Lipo Injection Technique' about 50 c.c or even more fat can be injected in one sitting itself. This procedure brings noticeable difference and is very durable.
It took a period of seven years for Dr. Singh to develop these techniques before he presented two original papers on Liposuction and Lipoinjection in the Congress of the International Confederation for Plastic, Reconstructive and Aesthetic Surgery in San Francisco, California, USA in the year 1999. His techniques of Liposuction and Lipoinjection were accepted and applauded in the World Congress on Cosmetic Surgery at Sydney, Australia, in the year 2001. Infact, he is the only surgeon from South East Asia whose improved techniques have been accepted worldwide.
From being a taboo subject for the past half a century, Plastic and Cosmetic surgical techniques have received a well-deserved facelift in the last two decades. People around the world are slowly understanding the immense changes that these techniques could bring in one's life. Now the people who have any physical deformity need not spend their entire lives keeping a low profile behind closed doors. With the help of Plastic and Cosmetic surgery everybody can gain the much needed confident and smart look to live one's life to the brim. ****


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Mar18
Integrated approach in the management of cerebral palsy:
Introduction-- Whenever, a child is diagnosed as cerebral palsy, the idea which comes to the our mind that he is suffering from permanent brain damage and will be permanently disable for life. This Child will not be able to start their normal routine activities in time; besides that this child may be suffering from other associated problem like difficulty in hearing, vision, fits, dribbling of saliva and mental retardation. Until now, it was believed that in the absence of effective treatment these children can not do their daily activity on their own for whole life and they have to dependent on others and it was also thought that their life expectancy will be short. Most of time parents used to wander from pillar to post in the hope of best advice and treatment. We always in dilemma regarding unpredictable out come. But truth is for away from this fact. These children can survive up-to the age of normal population with good quality of life if they have given good treatment. Recently, due to new concept of OSSCS and availability of fully trained developmental therapist, great success has been achieved in most of these children. All new technique and concept have been included in the integrated approach. Integrated approach involves primary modality like sensory integration, neuro-developmental therapy, strength training exercises, braces, and intervention modality like botulinum toxin and OSSCS surgical technique. With this holistic approach most of our children can be given fruitful life and they can be integrated in main stream of society. Treatment of cerebral palsy requires team approach so that all these special children with cerebral palsy should not be suffering in inexperienced person.
Definition - The term cerebral palsy is taken from Latin term “Damaged Brain’ and also known as static encephalopathy. Cerebral Palsy is defined as group of disorder of movement and posture caused by a non progressive defect in immature brain by any insult from prenatal period to 2.5 years of post natal period.
Incidence -- Incidence is 0.6-5.9 per thousand live births. Cerebral palsy is 27 times more common in children of <1.5 Kg. as compared to 2.5 Kg. It is commonest cause of severe physical disability in childhood and constitutes largest group of pediatric patient with neuromuscular disease. With the availability of good neonatal intensive care unit, increasing number of pre term and low birth weight baby are being saved, the number of children with cerebral palsy is increasing day by day.
Etiology: Exact etiology in most of the cases with cerebral palsy is not clear. Cerebral palsy can occur due to variety of causes. Any insult of brain from prenatal period to 2.5 year postnatal period can cause cerebral palsy.
Prenatal risk factors -- intrauterine infection, toxemia and toxic drugs, multiple pregnancy, placental insufficiency.
Perinatal risk factors -- Prematurity, low birth Weight, neonatal asphyxia, kernicterus, septicemia, and respiratory distress syndrome, obstructed labor , infant on ventilator for more than 4 week
Post natal risk factor-- head injury and infection.
Pathophysiology of cerebral palsy: The immature partially damaged brain attempts to heal itself but falls short and the results are a fixed anatomical deficit. Peripheral manifestation depends upon the magnitude, extent and location of insult to brain. Damage to brain is one time event so condition does not change but its effect may change with time. Aging has negative effect on joint due to abnormal posture and rigidity.
In spastic cerebral palsy Velocity dependent increase in tonic stretch reflex occurs because of a loss of inhibition in the basic neurological circuit of reflex arch normally under many modulatory influences (pyramidal tract). Unrelieved spasticity leads to fixed contracture, torsional deformity of bone and joints and dislocation during period of growth (Cosgrove & Graham 1994).
Athetoid cerebral palsy is resultant of injury to extra pyramidal systems and ataxic variety is due to cerebellar damage.
Clinical presentation— Every child with cerebral palsy is unique in presentation. Presentation of Cerebral palsy can be very wide from sever global dysfunction of mental and physical ability to isolated slight disturbances in gait, cognition, growth, or sensation .
Whole Problem seen in child with Cerebral Palsy-
Developmental milestone: Delayed gross motor, fine motor etc...
Mobility: Poor postural control, in coordination, poor balance, involuntary movement etc…
Cognition: Attention, concentration, memory etc.
Self care: Dependent/ partial dependent in basic ADL (feeding, dressing etc...)
Social: communication, social behaviour (verbal & non verbal)
Academic: Maintaining posture, hand function etc
Associated Handicap: Associated problem define ultimate outcome in management of cerebral palsy. 1. Speech problem - 82%, 2. Mental Retardation -19%, 3. Deafness-15%, 4. Visual defect-34%, 5. Perceptual problem-14%, 6.Convulsive disorders (25%)
Other associated problems are
7. Mental retardation 8. Dental defects 9. Chest congestion 10. Sleeping disorder 11.Poor immunity 12.Growth retardation 13. social and emotional problems 14. Spinal defects 15. Bladder and bowel problems 16. Feeding problems 17. Constipation 18.Obesity 19. Malnourishment 20. learning disability
Clinical Classification: 1) Spastic- Commonest (70-80%) 2. Dyskinesia : a) Athetosis b) Chorea c) Ballismus d) Tremor e) Dystonia 3) Atonia 4) Ataxia 5) Mixed
Topographical Classification: Cerebral palsy can involve single extremity to all four extremities depending upon extant of brain damage. Pattern of involvement are 1) Monoplegia 2) Hemiplegia 3) Diplegia 4) Triplegia 5) Quadriparesis 6) Paraplegia 7) Double plegia

Diagnosis: Diagnosis of cerebral palsy is based mainly on detail history and clinical examination. MRI and CT scan are advisable in some cases to rule out other problem. EEG is required in child with history of epilepsy. Genetic and metabolic tests are carried out in the case of family of affected sibling with progressive deterioration.
Early Identification— we can identify children with cerebral palsy in an early stage with the help of regular screening in all high risk babies.
Cerebral palsy can suspected on following feature. History of:- Premature birth, Difficult delivery, Asphyxia, Septicemia , Jaundice , Delayed motor mile stones like poor head control, inability to sit and stand , Asymmetry in functional use of extremities. , Difficulty in feeding and drooping of saliva, abnormally increase or decrease in tone. , Involuntary movement. , Abnormal persistence of primitive reflexes & associated problems like mental retardation , speech problem, hearing loss, squint & seizure
Aims & Principles of Management: We don’t have any permanent cure of cerebral palsy as brain damage can not be repaired. Aim of treatment is to increase the patient’s assets as much as possible & minimize his deficit. With proper management, we can diminish the functional impairment up to great extant in most of the children. Regardless of their mental capacity, almost all patients can be taught something about self-care, mobility and communication. Treatment should focus on child’s ability, not disability and method should be evolved to enhance utilization of his ability. It has been seen that with improvement in their physical condition, child also improve a lot in their cognition and their personality.
Integrated approach--- Concept of integrated approach is to use all available proven modality of therapy and intervention modality in a combination to prevent permanent consequences like bony torsion, dislocation and decompensated changes in joint and if it happen then it should be treated early so that child can be given a good chance of recovery early without loosing important time of life. It requires multidisciplinary approach.
Prognosis-- Approximately 85% of partially involved children have the potential to become independent ambulators. Life expectancy is normal in most diplegic and hemiplegic children, who receive adequate medical care and have strong family support. The survival rate of severely affected quadriplegics is dependent upon associated disability and care given to child.
Good Prognostic Value—1. Mild mental retardation to good IQ 2. Spastic variety 3. Diplegic, and hemiplegic 4. Good family support 5. Early identification and early intervention from 3 month to 6month. 6. Good neck holding and spinal balance.
Poor prognostic value --- 1. Moderate to sever mental retardation 2. Abnormal behavioral pattern 3. Athetotic and mixed cerebral palsy 4. Quadriplegic with sever contracture in early age 5. Absent neck holding after 4 year age 6. Absent Sitting and standing capability even with support after 6 year of age
Criteria for Treatment Modality— 1. Age 2. Developmental mile stones 3. Degree of contracture and deformity 4. Sensory and propioceptive problems 5. Degree of spasticity
Modality of treatment in cerebral palsy---
Primary modality of treatment--- We should emphasized that therapist should be well trained in the management of developmental therapy otherwise child can deteriorate with improper physiotherapy. Parents should be fully trained in home based therapy Programme by therapist incharge of child so that they can carry out therapy at home.
• Physiotherapy – sensory integration, neuro-developmental therapy, stretching and strength training exercise, gait training and balancing exercise.
• Hydrotherapy (aquatic therapy)-- Exercise in water appeals to children with CP because of the unique quality of buoyancy of water that reduces joint loading and impact, and decreases the negative influences of poor balance and poor postural control.
• Hypnotherapy (horse riding)-- Therapeutic riding can facilitate cognitive and sensor motor development in childhood, help develop a sense of responsibility, self-confidence and fair play in adolescence and provide life-long recreation and sport. It can do all this while stimulating the good posture, balance and flexibility needed for functional independence off the horse
• Early intervention--Treatment of child with cerebral palsy start from ICU itself. It has been shown that with early intervention most of the children can lead to normal life (>80%). Sensory integration, range of motion exercise and positioning of infant has a great role in early intervention. We should be causes in high risk children.
Braces, Night Splint and Mobility Aid: The goals of bracing are to increase function, prevent deformity, keep the joint in the functional position, stabilize the trunk and extremities and facilitate selective motor control. Now only light weight braces made up of polypropylene is being used. Traditional metal and leather caliper has no place in management of cerebral palsy
• BRACES (AFO, Gaiter, Spinal frame) - helps in balancing ex. and gait training
• NIGHT SPLINT- keeps muscle in maximum stretched position.
• MOBILITY AID (Walker, Relaters, Tripod etc) - helps in mobilization
Intervention modality ---
Repeated Corrective Plaster Application--- It helps in correction of Static Muscular Contracture. It is indicated in Mild to moderate contracture and useful only in foot, ankle and knee problem. Plaster application after botulinum toxin injection enhances effect of spasticity reduction. But it is not indicated in cases with very sever contracture, dislocation and bony deformity. And it is very cumbersome and some time it leads to incomplete correction.
Anti spastic treatment-- Baclofen & Tizanidine has been used as oral antispastic treatment. But it causes drowsiness and generalized muscle weakness so only short term use is advisable. Intrathecal Baclofen is indicated mainly in generalized and quadriplegic CP. But complication rate are very high and very costly. Local Nerve block by Phenol and alcohol can be done but it can cause sensory loss, disasthesia and some time irreversible muscle fibrosis and contracture.
Botulinum Toxin – Botulinum toxin is a powerful toxin which has been misused for biological warfare in the past. Its effect last for only 3 to 4 month but the duration of response can be prolonged up to some extent by use of serial cast, day night splint & good physiotherapy. It acts pre-synoptically by blocking the release of the neuro-transmitter acetyl-choline at the NM junction. It does not kill neurons but causes temporary and ultimate reversible blocked of cholinergic transmission. It is Effective in only Spastic CP and it Facilitate better Physiotherapy & nursing care. Agonist Muscles can be strengthen in better way This toxin exerts its effect beyond the injection site in the form of relief of sustained abnormal posture. Side Effects are Very-2 rare. Transient weakness, Swelling, bruising and calf pain, Skin rashes, Flue like syndrome. Asthenias, Urinary Incontinence are the some minor complication. Due to short term effect, it is being used repeatedly every six month. It is not very effective in elder children with contracture so we have stop using in elder children and we use only in children of 2 to 5 year age group with sever spasticity and with the purpose to facilitate better physiotherapy and to post pone OSSCS till age of 5 year
Neurosurgical intervention--
1. Selective posterior Rhizotomy-- Selective Dorsal Rhizotomy (SDR) is a surgical procedure in which some of the sensory nerve fibers coming from the muscles to the spinal cord are cut. Its effects are permanent. Some time it can cause disabling and permanent weakness in limbs.
2. Neurectomy- Now this surgery is not being done. It causes permanent weakness and fibrosis of muscles.
Orthopedic surgical intervention:
1. Routine Orthopedic surgery-- Orthopedic surgery is typically recommended when fixed deformities results in stalled motor progress, pain, Orthotic intolerance & difficulties with care. Orthopedic surgery primarily involves fractional lengthening and tenotomy, muscle transfers, joint reconstruction, bone fusions, or bone realignment. Improper planning can lead to walking child into non-walker.
Problem arises from routine orthopedic surgery— With routine orthopedic surgery, some time ambulatory patient became non-ambulatory and Reverse deformity may develop ( Eq, genu recurvatum and weakness of tendoachilis). Surgery is being considered in staged manner so child requires repeated surgery. We are not able to correct spasticity, athetosis, torsional deformity and Lever arm dysfunction by this surgery. Routinely this surgery is being done in later phase of childhood life at 9-12 year age, when torsional deformity and joint disintegration has been already settled.
This entire problem can be tackle by OSSCS and lever arm restoration surgery in a better ways (functional orthopedic surgery) so we have stop doing routine orthopedic surgery in children with cerebral palsy.
RECENT ADVANCEMENT
1. Orthopedic Selective Spasticity Control Surgery—
• OSSCS is an orthopedic procedure, designed to control or reduces all kinds of hypertonicity such as spasticity, rigidity and athetosis in cerebral palsy.
• This surgical technique is based on concept of multi-articular spastic muscle. Long multi-articular muscle has more propensity of spasticity that weakens antigravity and voluntary activity of short mono articular muscle. Hypertonicity of the multi-articular muscles causes abnormal hypertonic posture.
• When the multi-articular muscles are lengthened or sectioned selectively, hypertonicity is reduced & the mono-articular muscles are preserved and facilitated. Selective spasticity control may allow many patients with CP to use motor control more effectively and functionally.
• Earlier thought was that, result of surgery in cerebral palsy is unpredictable, some feel better and some worse following surgery. Now with the advance technique and well planned surgery, child always became better.
• Contracture and bony deformities are almost inevitable in a growing child with spastic diplegia and need surgical intervention in the form of OSSCS at proper time to prevent joint de-compensation and over-lengthening of tendon. Now surgery is being considered an important incident in total management of patient with cerebral palsy.
• OSSCS+ Multi Level Lever Arm Restoration (bony correction) treats a wide range of problems in motor activities and activities of daily living and provide new path for functional improvement and for active life styles in most patients with cerebral palsy.
• Well performed surgery on properly selected patient give good result provided the treatment after surgery is carefully managed. Successful surgery give all round acceleration of other function like learning, speech, behavior along with motor function recovery .
• There will be No loss of antigravity activity, No loss of sensation and stereognosis and No increase in deformity is going to happen.
• Surgery should not be delayed to long, otherwise progressive deformity and co- spasticity of muscles will lead to de-compensated changes in joint and bone and makes gaits laborious, energy consuming and inefficient. Early surgery shortens the period of therapy even for years. OSSCS on lower limb is being performed in age group of 4-6 year and upper limb between 6-8 year ages. Although it can be done at any age group with proper indication.
• In upper extremity it helps to improve the ability to turn over, to crawl and to use crutches.
• It helps in acquiring rolling, crawling, sitting, kneeling, standing and independent gait.
• Orthopedic selective spasticity control surgery is quite a reliable and promising procedure for patients, parents, physiotherapists and occupational therapists and even for school teachers.
2. Simultaneous correction of lever arm dysfunction – Disruption in the moment generation of a muscle joint complex due to an ineffective lever arm moment despite normal muscle force results in Functional weakness and decrease in power generation. Correction of lever arm dysfunction like tibial torsion, anteversion of femoral neck and subluxation of femoral head can be treated simultaneously so that muscle forces start working in balance manner. Due to complexity of problem in these children, there is only few indication of multi level lever arm restoration in children with cerebral palsy. First we should try OSSCS (soft tissue surgery) to make non ambulatory child into ambulatory capability. Indication are Subluxation (> 40%) and dislocation of hip joint, Moderate to sever tibial torsion, Plano valgus feet not correctible by soft tissue surgery m and child with ambulatory capacity want to improve their gait pattern.

3. Single stage multilevel corrective surgery (SEMLS) -- Now days all deformity in body is being corrected by multilevel OSSCS in a single setting anesthesia to save child from repeated surgery (I.e. BIRTHDAY SYNDROME).
Conclusion-- In this new era of latest concept, most of our children can be given a fruitful life and even they can be intergraded in main stream of society. Early intervention always gives good functional outcome. Botulinum toxin and OSSCS surgical technique has became a boon for these children. Holistic approach to Management requires multidisciplinary team, in which role of fully trained and dedicated developmental therapist and family member can’t be ignored. Otherwise result of any intervention will be fruitless. There should be proper coordination between therapist and pediatric orthopedic surgeon.
References—
1. Gage JR, Novacheck TF. An update on the treatment of gait problem in cerebral palsy. J Pediatr Orthop 2001; 10:265-271.
2. Badell A. The effect of medication that reduces spasticity in the management of spastic Cerebral Palsy. J Neuro Rehab 1991; 5(suppl1) 513-514.
3. Boboth B, Boboth K. The neurodevelopment Treatment. In srutten D, Ed. Management of the motor disorder of children with cerebral palsy. Philadelphia; Lipincott, 1984; 6-18.
4. Matsua T. cerebral palsy: spasticity control and Orthopaedic. An introduction to orthpaedic selective spasticity control surgery (OSSCS). Soufusha. Japan: 2002.
5. Miller F. Cerebral palsy. Springer.2005
6. Berker N, Yalcin S. The help guide to cerebral palsy. Global help publication.2005
7. Rosenbaum P. Cerebral palsy: what parents and doctors want to know? BMJ 2003;326:970–4


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Mar17
Metformin & PCOS
METFORMIN THERAPY FOR THE MANAGEMENT OF INFERTILITY IN WOMEN WITH POLYCYSTIC OVARY SYNDROME

1. Introduction

The key clinical features of polycystic ovary syndrome (PCOS) are hyperandrogenism (hirsutism,
acne, alopecia) and menstrual irregularity with associated anovulatory infertility.1 The consensus
definition of PCOS recognises obesity as an association and not a diagnostic criterion1 as only
40–50% of women with PCOS are overweight. Ovarian hyperandrogenism is driven primarily by
luteinising hormone (LH) in slim women, while in the overweight insulin may augment the effects of LH.1 Women with polycystic ovaries are more insulin resistant than weight-matched women with normal ovaries. Insulin resistance is seen in 10–15% of slim and 20–40% of obese women with PCOS and women with PCOS are at increased risk of developing type 2 diabetes.2

2. Insulin resistance

Insulin resistance is defined as a reduced glucose response to a given amount of insulin and usually
results from faults within the insulin receptor and post-receptor signalling. As a result circulating
insulin levels rise. Insulin resistance does not affect all actions of insulin and, in the ovary, high levels
of circulating insulin are thought to contribute both to excess androgen production and to anovulation. Insulin resistance can be measured by a number of expensive and complex tests but in clinical practice it is not necessary to measure it routinely; it is more important to check for impaired glucose tolerance.2 Simple screening tests include an assessment of body mass index (BMI) and waist circumference. If the fasting blood glucose is less than 5.2 mmol/l the risk of impaired glucose tolerance is low. The 2-hour standard 75 g oral glucose tolerance test (OGTT) may be conducted in those at high risk (BMI greater than 30 kg/m2 in white women or greater than 25 kg/m2 in women from South Asia, who have a greater degree of insulin resistance at a lower body weight).1,2

3. Metformin therapy for PCOS

Obesity has a profound effect on both natural and assisted conception, influencing the chance of
becoming pregnant and the likelihood of a healthy pregnancy.3 Increasing obesity is associated with
greater insulin resistance. Metformin inhibits the production of hepatic glucose, enhances insulin
sensitivity at the cellular level and also appears to have direct effects on ovarian function. It is logical
to consider, therefore, that insulin lowering and insulin sensitising treatments such as metformin and
the thiazolidinediones (rosiglitazone, pioglitazone) should improve the symptoms and reproductive
outcome for women with PCOS.4 Most of the initial studies of metformin in the management of PCOS were observational. Initial systematic reviews, in which the majority of studies had a small sample size and did not include a power calculation for the proposed effect, suggested that metformin when compared with placebo, had a significant effect on lowering serum androgen levels and restoring menstrual cyclicity and was effective in achieving ovulation either alone or when combined with clomifene.5 Subsequent larger randomised trials, however, have not substantiated these early positive findings. Furthermore, while some studies suggested that metformin therapy may achieve weight reduction,6 the large randomized controlled trials
and systematic reviews have failed to confirm this.5,7,11

Metformin appears to be less effective in those who are significantly obese (BMI greater than 35 kg/m2),6,7
although there is no agreement on predictors for response or the appropriate dose and whether dose
should be adjusted for body weight or other factors. Doses of between 500–3000 mg/day have been used
and the most common dose regimens are 500 mg three times daily or 850 mg twice a day. Long-acting
preparations are associated with fewer gastrointestinal adverse effects. Metformin appears to be safe in pregnancy, although usual advice is to discontinue once a pregnancy occurs. There is no firm evidence that metformin reduces the risk of either miscarriage or gestational diabetes.

The largest prospective randomised, double blind, placebo-controlled study trial to evaluate the combined effects of lifestyle modification and metformin (850 mg twice daily) studied 143 anovulatory women in the UK with a mean BMI of 38 kg/m.27 All subjects had an individualised assessment by a dietician in order to set a realistic goal that could be sustained with an average reduction of energy intake of 500 kcal per
day. As a result, both the metformin-treated and placebo groups managed to lose weight but the amount of weight reduction did not differ between the two groups. An increase in menstrual cyclicity was observed in those who lost weight, but again did not differ between the two arms of the study.7
In a Dutch trial, 228 women with PCOS were treated either with clomifene citrate (CC) plus metformin
or CC plus placebo.8 There were no significant differences in either rates of ovulation (64% versus
72%), continuing pregnancy (40% versus 46%) or rate of spontaneous miscarriage (12% versus 11%).
A significantly larger proportion of women in the metformin group discontinued treatment because of
adverse effects (16% versus 5%). The US Pregnancy in Polycystic Ovary Syndrome (PPCOS) trial9 enrolled 676 women for six cycles or 30 weeks, randomised to three treatment arms (metformin 1000 mg twice daily plus placebo, clomifene citrate plus placebo or metformin plus clomifene citrate). Overall, live birth rates were 7% (5/208), 23% (47/209) and 27% (56/209), respectively, with the metformin alone group being significantly lower than the other two groups. Miscarriage rates tended to be higher in the metformin alone group (40% versus 23% and 26%, respectively). Thus, it was concluded that as
first-line therapy for the treatment of women who are anovulatory and infertile with PCOS, metformin
alone was significantly less effective than clomifene citrate alone and that the addition of metformin to
clomifene citrate produced no significant benefit.9 Subgroup analysis of women with a BMI greater than
35 kg/m2 and in those with clomifene resistance did, however, suggest a potential benefit from the
combined use of metformin with clomifene citrate.9
It has been suggested that co-treatment with metformin may improve the response to exogenous
gonadotropins or the outcome of assisted reproduction therapy. Indeed, the largest study to date has shown an increase in continuing pregnancy rates in women with polycystic ovaries and a mean BMI of 28 kg/m2 treated with metformin (850 mg twice daily) for only 4 weeks during an IVF cycle.10 In this study, 101 women were randomised to receive metformin or placebo. Both the clinical pregnancy rates beyond 12 weeks of gestation per cycle started (39% versus 16%; P = 0.023) and per embryo transfer (44% versus 19%; P = 0.022) were significantly higher in those treated with metformin. Furthermore, a significant decrease in the incidence of severe ovarian hyperstimulation syndrome was observed (4% versus 20%; p=0.023) despite the higher pregnancy rate in the metformin arm of the study.10 These results are promising but further studies are required to confirm these observations before the place of metformin in assisted reproductive techniques can be clearly assessed.
The updated Cochrane review concluded that the benefit of using therapy to lower insulin levels such as metformin is limited in terms of improvement in reproductive outcome and metabolic parameters.11 In
SAC Opinion Paper 13 2 of 4 particular, the use of metformin either alone or in combination with drugs to induce ovulation such as clomifene citrate did not increase the chance of having a livebirth. Furthermore, despite evidence of a reduction in development of diabetes in a high risk non-PCOS population12 the long-term use of metformin in reducing the risk of developing metabolic syndrome is questionable.11 Lifestyle advice with
appropriate attention to diet and exercise has to be the mainstay for young women with PCOS.

4. Opinion

While initial studies appeared to be promising, more recent large randomised controlled trials have not
observed beneficial effects of metformin either as first-line therapy or combined with clomifene citrate
for the treatment of the anovulatory woman with PCOS. Most work has been undertaken in the
management of anovulatory infertility and there are no good data from randomised controlled trials on
the use of metformin in the management of other manifestations of PCOS. It is clear that the first aim
for women with PCOS who are overweight is to make lifestyle changes with a combination of diet and
exercise in order to lose weight and improve ovarian function. The European Society for Human
Reproduction and Embryology and American Society for Reproductive Medicine consensus on infertility
treatment for PCOS concluded that there is no clear role for insulin sensitising and insulin lowering drugs
in the management of PCOS, and should be restricted to those patients with glucose intolerance or type
2 diabetes rather than those with just insulin resistance.13 Therefore, on current evidence metformin is not a first line treatment of choice in the management of PCOS.

References

1. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003
consensus on diagnostic criteria and long-term health risks related to polycystic ovary
syndrome (PCOS). Hum Reprod 2004;19:41–7.

2. Legro RS, Castracane VD, Kauffman RP. Detecting insulin resistance in polycystic ovary syndrome: purposes and pitfalls. Obstet Gynecol Surv 2004;59:141–54.

3. Balen AH, Anderson R. Impact of obesity on female reproductive health: British Fertility
Society, Policy and Practice Guidelines. Hum Fertil 2007;10:195–206.

4. Kayshap S, Wells GA, Rosenwaks Z. Insulin-sensitizing agents as primary therapy for patients
with polycystic ovary syndrome. Hum Reprod 2004;11:2474–83.

5. Lord JM, Flight IH, Norman RJ. Insulin-sensitising drugs (metformin, troglitazone, rosiglitazone, pioglitazone, d-chiro-inositol) for polycystic ovary syndrome. Cochrane Database Syst Rev 2003;(2):CD003053 [DOI:10.1002/14651858. CD003053].

6. Fleming R, Hopkinson Z, Wallace A, Greer I, Sattar N. Ovarian function and metabolic factors in women with oligomenorrhoea treated with metformin in a randomized double blind placebo-controlled trial. J Clin Endocrinol Metabol 2002;87:569–74.

7. Tang T, Glanville J, Hayden CJ, White D, Barth JH, Balen AH. Combined life-style modification and metformin in obese patients with polycystic ovary syndrome (PCOS). A randomised, placebo-controlled, double-blind multi-centre study. Hum Reprod 2006;21:80–9.

8. Moll E, Bossuyt PM, Korevaar JC, Lambalk CB, van der Veen F. Effect of clomifene citrate plus metformin and clomifene citrate plus placebo on induction of ovulation in women with newly diagnosed polycystic ovary syndrome: randomised double blind clinical trial. BMJ 2006;24:332(7556):1485.

9. Legro RS, Barnhart HX, Schlaff WD, Carr BR, Diamond MP, Carson SA, et al. Cooperative
Multicenter Reproductive Medicine Network. Clomiphene, metformin, or both for infertility
in the polycystic ovary syndrome. N Engl J Med. 2007;356:551–66.

10. Tang T, Glanville J, Orsi N, Barth JH, Balen AH. The use of metformin for women with PCOS undergoing IVF treatment. Hum Reprod 2006; 21:1416–25.

11. Lord JM, Flight IHK, Norman RJ. Insulin-sensitising drugs (metformin, troglitazone, rosiglitazone, pioglitazone, D-chiro-inositol) for polycystic ovary syndrome. Cochrane Database Syst Rev 2008;(4):CD003053. SAC Opinion Paper 13 3 of 4

12. Diabetes Prevention Program Research Group. Reduction in the incidence of Type 2 diabetes
with lifestyle intervention or metformin. N Engl J Med 2002;346:393–403.

13. Thessaloniki ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Consensus on
infertility treatment related to polycystic ovary syndrome. Hum Reprod 2008; 23:462–77.


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Mar16
* Sub- Conscious Mind
* Sub- Conscious Mind



We all have this hidden part of mind and a little knowledge was available on it yet, but with our deep research on this part of mind, we have been able to understand it up to a certain limit. Its power can be realized by the fact that, with open eyes we can see a very short area i.e. our room or maximum up to an area of 1 km. But with closed eyes we can see any place in this entire universe. It is known to everyone that human mind has a maximum efficiency of 20%. This means that 80% of our mind remains unused throughout our life. It is because the conscious mind has a total working efficiency of 15% (approx.) and the rest 5% is given by Sub- Conscious mind. But, in reality our Sub- Conscious mind holds a total efficiency of the rest 85% but is never used. The Rishi Munees in ancient times of India used this Sub- Conscious mind and gained the knowledge of 'Vedas' which were later written down. We all have heard about people who have bent spoons just by staring at them or about Tibetan monks who can dry a wet piece of cloth just by putting it around there naked body in a winter season. A lot of such incidents are often heard from around the world. It is this Sub- Conscious mind which does the trick. It does not mean that those people have generated that power but in most of such cases, it is a God's gift to them and there Sub- Conscious mind is more efficient than others since birth. As we all are not the blessed ones, we are on our struggling path to achieve the bliss by researching and practicing on it.


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Mar16
understand ur friends
Once upon a time there was this girl who had four boyfriends.

She loved the 4th boyfriend the most and adorned him with rich robes and treated him to the finest of delicacies. She gave him nothing but the very best.

She also loved the 3rd boyfriend very much and was always showing him off to neighboring kingdoms. However, she feared that one day he would leave her for another.

She also loved her 2nd boyfriend. He was her confidant and was always kind, considerate and patient with her. Whenever this girl faced a problem, she could confide in him, and he would help her get through the difficult times.

The girls 1st boyfriend was a very loyal partner and had made great contributions in maintaining her wealth and kingdom. However, she did not love the first boyfriend. Although he loved her deeply, she hardly took notice of him!

One day, the girl fell ill and she knew her time was short. She thought of her luxurious life and wondered, I now have four boyfriends with me, but when I die, I'll be all alone."

Thus, she asked the 4th boyfriend, "I loved you the most, endowed you with the finest clothing and showered great care over you. Now that I'm dying, will you follow me and keep me company?"

"No way!", replied the 4th boyfriend, and he walked away without another word.

His answer cut like a sharp knife right into her heart.

The sad girl then asked the 3rd boyfriend, "I loved you all my life. Now that I'm dying, will you follow me and keep me company?"

"No!", replied the 3rd boyfriend. "Life is too good! When you die, I'm going to marry someone else!"

Her heart sank and turned cold.

She then asked the 2nd boyfriend, "I have always turned to you for help and you've always been there for me. When I die, will you follow me and keep me company?"

"I'm sorry, I can't help you out this time!", replied the 2nd boyfriend. "At the very most, I can only walk with you to your grave."

His answer struck her like a bolt of lightning, and the girl was devastated.

Then a voice called out: "I'll go with you. I'll follow you no matter where you go."

The girl looked up, and there was her first boyfriend. He was very skinny as he suffered from malnutrition and neglect.

Greatly grieved, the girl said, "I should have taken much better care of you when I had the chance!"

In truth, you have 4 boyfriend's in your lives:

Your 4th boyfriend is your body. No matter how much time and effort you lavish in making it look good, it will leave you when you die.

Your 3rd boyfriend is your possessions, status and wealth. When you die, it will all go to others.

Your 2nd boyfriend is your family and friends. No matter how much they have been there for you, the furthest they can stay by you is up to the grave.

And your 1st boyfriend is your Soul. Often neglected in pursuit of wealth, power and pleasures of the world.

However, your Soul is the only thing that will follow you where ever you go. Cultivate, strengthen and cherish it now, for it is the only part of you that will follow you to the throne of God and continue with you throughout Eternity.

Thought for the day: Remember, when the world pushes you to your knees, you're in the perfect position to pray.

Being happy doesn't mean everything's perfect. It means you've decided to see beyond the imperfections.


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Mar14
Joint Conservation Surgery
This article describes the evolution of replacement surgery to joint conservation in the West and its implications for India

There is a feverish spread of joint replacement surgery in the country. Everyone who is anyone is now talking about joint replacements as the panacea for pain.

Joint replacements have been around since before the second world war when English surgeons first attempted replacement surgery with metal on metal articulations at the hip. But it was in the early sixties that John Charnley first showed that hip replacements can be durable with his metal on plastic articulation and can be done by others other than the inventor (Sir John had this strict condition that nobody did his hip unless they were trained by him in his centre and the manufacturer would not sell the implants). He thereby ensured that well meaning enthusiastic adopters of his technology did not bring his hip into disrepute with failures.

Since then there has been a veritable explosion of developments in other joints. The Americans came out with knee replacements and then came replacements for shoulders/elbows/ankles/fingers and toes. Not all joint replacements are created equal. Hips and knees have been around the longest and hence we have enormous data demonstrating their success. Next came the shoulder and the elbow. Ankle replacements have been moderately successful but still cannot match the durability of their counterparts in the hip and knee.

Various series published by American and European surgeons have shown 95-97% survival at 10 years among knee and hip replacements. Put another way, the patient will know 15 years hence that his surgeon was good.

This frenzy of developments led to a geometric increase in replacement surgery in the West. With the enthusiastic adoption of joint replacements, inevitably there were instances of inappropriate selection of patients, done poorly by inexperienced surgeons which led to disaster. India has probably entered this phase.

In the West, Revision surgery is now a major percentage of knee and hip surgical practice. It is more expensive- requiring resources like bone banks to replace lost bone and experienced surgeons. Revision joint replacements are more extensive and done in much older patients and do not have similar survival statistics as the first primary replacement.

Hence the renewed interest in joint conservation surgery to prolong the life of the native joint for as long as possible until it is replaced.

Cartilage regeneration techniques like microfracture, cartilage cell transplantation, or cartilage-bone transplants either from the same knee or from a donor knee when done appropriately can prolong the native joint’s life sufficiently enough for at least a few years. This is especially good news for younger patients in their 40s and early 50s for whom a knee replacement at that stage will condemn them to at least one if not two revision surgeries in their lifetime, given the longevity of people with modern medicine.

Knees have three compartments –inner, outer and knee cap. Arthritis when localised to one compartment can either be treated by bone realignment to prevent arthritis in the other compartment or that compartment can be replaced in isolation. This kind of Unicondylar Knee Replacement(UKR) is an elegant solution which preserves the patient’s bone stock for a later Total Knee Replacement(TKR).

There are several types of UKRs. Oxford and St.Georg Sled from Europe have been around the longest with excellent survival rates of nearly 98% at 10 years for the Oxford knee, which was first developed in the University of Oxford-hence the name.

Such excellent results can only be obtained by careful selection of patients, meticulous technique and good long term follow up by the same surgeon. This gives the patient an extra decade of life without a major joint replacement.

Isolated knee cap replacements (Patello-Femoral joint arthroplasty – PFJA) are also a good answer to the sometimes vexing problem of knee cap arthritis with an otherwise pristine knee – in which case performing a TKR is unnecessary and unwarranted.

Again European joints like the Avon and Cartier have shown good results. A newer development is the Deuce from the USA which replaces two compartments including the patellofemoral joint.

When you consider the hip, resurfacing hip arthroplasty has the same advantage as the UKR in preserving bone. Prof Ganz in Bern, Switzerland has shown the importance of treating impingement at the hip early on to delay arthritis from developing.

In the shoulder, resurfacing implants like the Copeland or the shoulder cap developed by Miniaci from Cleveland USA again preserve bone for later total replacements.

Such developments show the importance that the orthopaedic community in the developed nations gives to the preservation of the natural joint. This has evolved from the earlier propensity of joint replacements at the drop of a proverbial hat.

However in a developing country like India, such options are expensive. The joint preservation options are not cheap by any means and are available only to those who understand the balance between quality of life issues and money. Furthermore, people who consider joint preservation should understand that these techniques can sometimes slow down arthritis and even give them the option of one primary replacement in their entire lifetime without the possibility of revision surgery. Like all operations, they come with complications like infection which if it happens can always be revised to a full joint replacement unlike an infected primary replacement which will require a full fledged Revision surgery with its attendant problems.


Category (Muscles, Bones & Joints)  |   Views (14945)  |  User Rating
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